PMID- 30266253
OWN - NLM
STAT- MEDLINE
DCOM- 20190829
LR  - 20190829
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 122
IP  - 11
DP  - 2018 Dec 1
TI  - Prevalence and Prognostic Impact of Septal Late Gadolinium Enhancement in Acute 
      Myocarditis With or Without Preserved Left Ventricular Function.
PG  - 1955-1958
LID - S0002-9149(18)31737-5 [pii]
LID - 10.1016/j.amjcard.2018.08.038 [doi]
AB  - Recent data suggest that myocardial septal late gadolinium enhancement (LGE) may 
      have an independent prognostic value in patients with acute myocarditis 
      undergoing cardiac magnetic resonance (CMR). Aim of the present study is to 
      evaluate its prevalence and prognostic implications in these patients with or 
      without preserved LV function. Retrospective cohort study including all cases of 
      clinically suspected acute myocarditis referred for CMR. A diagnosis of acute 
      myocarditis was confirmed by CMR according to Lake Louise Criteria. 
      Cardiovascular mortality, heart failure, heart transplantation, and sustained 
      ventricular arrhythmias were considered adverse events at follow-up. Seventy-one 
      patients were included in the present study (mean age 47 years 95% confidence 
      intervals 42 to 51, 53 males; 75%). Left Ventricular Ejection Fraction (LVEF) was 
      preserved in 45 cases (63%) and pericardial effusion was detected in 26 cases 
      (38%). CMR was performed at a mean time of 11 days (95% confidence intervals 7.5 
      to 14.4) from symptoms onset. Myocardial hyperemia and edema were detected in 53 
      cases (75%), myocardial LGE in 66 cases (93%). Septal LGE was reported in 21 
      cases (30%). After a mean follow-up of 60.8 months, the mean LVEF increased from 
      51.6 +/- 14.0% to 56.6 +/- 10.9% (p = 0.021) and combined adverse events were only 
      recorded in 4 patients (6%) with reduced basal LVEF. These patients had more 
      commonly septal LGE (respectively 58% vs13%, p <0.0001). However, on 
      multivariable analysis septal LGE had no additional predictive value over reduced 
      basal LVEF. In conclusion, our study suggests that septal LGE is not uncommon in 
      patients with acute myocarditis but has no added prognostic value over reduced 
      LVEF at presentation.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Imazio, Massimo
AU  - Imazio M
AD  - University Cardiology, Cardiovascular and Thoracic Department, AOU Citta della 
      Salute e della Scienza di Torino, Torino, Italy. Electronic address: 
      massimo_imazio@yahoo.it.
FAU - Angelico, Gloria
AU  - Angelico G
AD  - University Cardiology, Cardiovascular and Thoracic Department, AOU Citta della 
      Salute e della Scienza di Torino, Torino, Italy.
FAU - Andriani, Monica
AU  - Andriani M
AD  - University Cardiology, Cardiovascular and Thoracic Department, AOU Citta della 
      Salute e della Scienza di Torino, Torino, Italy.
FAU - Lobetti-Bodoni, Luisa
AU  - Lobetti-Bodoni L
AD  - Radiology Department, AOU Citta della Salute e della Scienza di Torino, Torino, 
      Italy.
FAU - Davini, Ottavio
AU  - Davini O
AD  - Radiology Department, AOU Citta della Salute e della Scienza di Torino, Torino, 
      Italy.
FAU - Giustetto, Carla
AU  - Giustetto C
AD  - University Cardiology, Cardiovascular and Thoracic Department, AOU Citta della 
      Salute e della Scienza di Torino, Torino, Italy.
FAU - Rinaldi, Mauro
AU  - Rinaldi M
AD  - University Cardiology, Cardiovascular and Thoracic Department, AOU Citta della 
      Salute e della Scienza di Torino, Torino, Italy; Cardiac Surgery, Cardiovascular 
      and Thoracic Department, AOU Citta della Salute e della Scienza di Torino, 
      Torino, Italy.
LA  - eng
PT  - Journal Article
DEP - 20180913
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Acute Disease
MH  - Contrast Media/pharmacology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Gadolinium/*pharmacology
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnosis/physiopathology
MH  - Myocardium/*pathology
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Stroke Volume/*physiology
MH  - Ventricular Function, Left/*physiology
EDAT- 2018/09/30 06:00
MHDA- 2019/08/30 06:00
CRDT- 2018/09/30 06:00
PHST- 2018/06/07 00:00 [received]
PHST- 2018/08/07 00:00 [revised]
PHST- 2018/08/13 00:00 [accepted]
PHST- 2018/09/30 06:00 [pubmed]
PHST- 2019/08/30 06:00 [medline]
PHST- 2018/09/30 06:00 [entrez]
AID - S0002-9149(18)31737-5 [pii]
AID - 10.1016/j.amjcard.2018.08.038 [doi]
PST - ppublish
SO  - Am J Cardiol. 2018 Dec 1;122(11):1955-1958. doi: 10.1016/j.amjcard.2018.08.038. 
      Epub 2018 Sep 13.