PMID- 30266584
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20191210
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 197
DP  - 2018 Dec 1
TI  - Neonatal handling impairs intradimensional shift and alters plasticity markers in 
      the medial prefrontal cortex of adult rats.
PG  - 29-36
LID - S0031-9384(18)30376-7 [pii]
LID - 10.1016/j.physbeh.2018.09.015 [doi]
AB  - Stress response can be modulated by neonatal/childhood events. Neonatal handling 
      (NH) is an animal model in which the animals are subjected to brief separations 
      from the dam during the first days of life, and it leads to lower emotionality 
      and behavioral changes in adulthood. The aim of this study was to observe if 
      early events, such as (NH), may program associative learning and behavioral 
      flexibility in adult male rats and if these changes could be related to altered 
      neurochemistry in the medial prefrontal cortex (mPFC). We evaluated proteins 
      related to synaptic plasticity (brain-derived neurotrophic factor [BDNF] and 
      synaptophysin [SYP]) as well as Na(+)/K(+)-ATPase activity. Additionally, we 
      evaluated proteins related to the dopaminergic system (tyrosine hydroxylase [TH] 
      and phosphorylated TH [pTH]), since this system appears to be affected in some 
      neonatal interventions. Neonatally handled animals exhibited impairment in simple 
      discrimination and intradimensional shift but not in reversal or compound 
      discrimination; in addition, no alteration in switching from an egocentric 
      spatial to a cued strategy was observed. These effects were accompanied by a 
      decrease in SYP levels and Na(+)/K(+)-ATPase activity, suggesting reduced 
      synaptic function. These results indicate that NH increases attention to 
      irrelevant stimuli and/or impairs associative learning, and this is accompanied 
      by neurochemical alterations in the (mPFC).
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Lazzaretti, Camilla
AU  - Lazzaretti C
AD  - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da 
      Saude (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, 
      RS, Brazil; Centro Universitario Cenecista de Osorio (UNICNEC), Osorio, RS, 
      Brazil. Electronic address: camilla.lazzaretti@yahoo.com.br.
FAU - Kincheski, Grasielle Clotildes
AU  - Kincheski GC
AD  - Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
FAU - Pandolfo, Pablo
AU  - Pandolfo P
AD  - Universidade Federal Fluminense (UFF), Rio de Janeiro, RJ, Brazil.
FAU - Krolow, Rachel
AU  - Krolow R
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - Toniazzo, Ana Paula
AU  - Toniazzo AP
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - Arcego, Danusa Mar
AU  - Arcego DM
AD  - McGill University, Montreal, Quebec, Canada.
FAU - de Sa Couto-Pereira, Natividade
AU  - de Sa Couto-Pereira N
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - Zeidan-Chulia, Fares
AU  - Zeidan-Chulia F
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - de Oliveira, Ben-Hur Neves
AU  - de Oliveira BN
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude (ICBS), 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
FAU - Bertolini, Diego
AU  - Bertolini D
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude (ICBS), 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
FAU - Breunig, Raquel Luisa
AU  - Breunig RL
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude (ICBS), 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
FAU - Ferreira, Andrea Kurek
AU  - Ferreira AK
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - Kolling, Janaina
AU  - Kolling J
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - Siebert, Cassiana
AU  - Siebert C
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - Wyse, Angela Teresinha
AU  - Wyse AT
AD  - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto de 
      Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
FAU - Souza, Tadeu Mello E
AU  - Souza TME
AD  - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da 
      Saude (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, 
      RS, Brazil; Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude 
      (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, 
      Brazil.
FAU - Dalmaz, Carla
AU  - Dalmaz C
AD  - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da 
      Saude (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, 
      RS, Brazil; Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica, 
      Instituto de Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande 
      do Sul (UFRGS), Porto Alegre, RS, Brazil; Departamento de Bioquimica, Instituto 
      de Ciencias Basicas da Saude (ICBS), Universidade Federal do Rio Grande do Sul 
      (UFRGS), Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180925
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Synaptophysin)
RN  - 0 (Syp protein, rat)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Attention/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Executive Function/physiology
MH  - *Handling, Psychological
MH  - Learning/physiology
MH  - Learning Disabilities/etiology/*metabolism
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Prefrontal Cortex/*growth & development/*metabolism
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Stress, Psychological/*metabolism
MH  - Synaptophysin/metabolism
MH  - Tyrosine 3-Monooxygenase/metabolism
OTO - NOTNLM
OT  - Attentional set shifting task
OT  - Biochemical parameters
OT  - Neonatal handling
OT  - Prefrontal cortex
OT  - Task switching
EDAT- 2018/09/30 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/09/30 06:00
PHST- 2018/06/17 00:00 [received]
PHST- 2018/09/24 00:00 [revised]
PHST- 2018/09/24 00:00 [accepted]
PHST- 2018/09/30 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/09/30 06:00 [entrez]
AID - S0031-9384(18)30376-7 [pii]
AID - 10.1016/j.physbeh.2018.09.015 [doi]
PST - ppublish
SO  - Physiol Behav. 2018 Dec 1;197:29-36. doi: 10.1016/j.physbeh.2018.09.015. Epub 
      2018 Sep 25.