PMID- 30267529
OWN - NLM
STAT- MEDLINE
DCOM- 20190110
LR  - 20190110
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 30
IP  - 3
DP  - 2018 Sep
TI  - Prenatal exposure to modafinil alters locomotor behaviour and leucocyte 
      phagocytosis in mice.
PG  - 356-366
LID - 10.24869/psyd.2018.356 [doi]
AB  - BACKGROUND: Modafinil is a psychostimulant drug prescribed mainly for treatment 
      of narcolepsy but is used as a "smart drug" by wide populations to increase 
      wakefulness, concentration and overall mental performance. The aim of this study 
      was to assess potential developmental toxicity of modafinil. MATERIALS AND 
      METHODS: Pregnant female mice were given either saline or modafinil (50 mg/kg 
      orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 
      17. The male offspring were treated analogously at the age of 10 weeks. Changes 
      in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the 
      open-field test were assessed in naive animals, after an acute and 8(th) 
      modafinil dose and the challenge dose following a 7-day wash-out period. One 
      month after completion of the behavioural study, the leukocyte phagocytosis was 
      examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. 
      RESULTS: The most important finding of this study was the immunosuppressing 
      effect on leukocyte activity, hypolocomotion and increased behavioural response 
      to modafinil-induced psychostimulation caused by prenatal exposure to the same 
      drug. We did not detect significantly altered anxiety-related behaviour in any 
      group disregarding the pre- and postnatal treatments. CONCLUSION: This is the 
      first evidence of developmental toxicity of modafinil which needs to be taken 
      into account as a potential risk factor when modafinil is administered to women 
      who may become or are pregnant.
FAU - Ruda-Kucerova, Jana
AU  - Ruda-Kucerova J
AD  - Masaryk University, Faculty of Medicine, Department of Pharmacology, Kamenice 5, 
      625 00 Brno, Czech Republic, jkucer@med.muni.cz.
FAU - Amchova, Petra
AU  - Amchova P
FAU - Machalova, Alena
AU  - Machalova A
FAU - Pistovcakova, Jana
AU  - Pistovcakova J
FAU - Sulcova, Alexandra
AU  - Sulcova A
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
RN  - 5EXP385Q4F (Luminol)
RN  - R3UK8X3U3D (Modafinil)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - *Disease Models, Animal
MH  - Female
MH  - Gestational Age
MH  - Leukocytes/*drug effects
MH  - Locomotion/*drug effects
MH  - Luminescent Measurements
MH  - Luminol
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Modafinil/*adverse effects
MH  - Phagocytosis/*drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
EDAT- 2018/09/30 06:00
MHDA- 2019/01/11 06:00
CRDT- 2018/09/30 06:00
PHST- 2018/09/30 06:00 [entrez]
PHST- 2018/09/30 06:00 [pubmed]
PHST- 2019/01/11 06:00 [medline]
AID - 10.24869/psyd.2018.356 [doi]
PST - ppublish
SO  - Psychiatr Danub. 2018 Sep;30(3):356-366. doi: 10.24869/psyd.2018.356.