PMID- 30267610
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 66
IP  - 1
DP  - 2019 Jan
TI  - A novel NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) 
      plays a limited role in the pathogenicity of porcine circoviruses (PCV2 and PCV3) 
      and PRRSV co-infection.
PG  - 28-34
LID - 10.1111/tbed.13026 [doi]
AB  - Co-infection of porcine reproductive and respiratory syndrome virus (PRRSV) and 
      porcine circoviruses (PCVs) is commonly observed under field conditions and 
      elicits more severe diseases than any singular infection. In this study, the 
      co-infection of PRRSV, PCV2 and PCV3 was analyzed in tissue samples collected 
      from 150 pigs from April 2016 to April 2018. PRRSV, PCV2 and PCV3 was detected in 
      55 (36.67%), 43 (28.67%) and 3 (2%) of 150 pigs respectively. Remarkably, one 
      lung sample (SD17-36) collected from a diseased pig was co-infected with PRRSV, 
      PCV2 and PCV3. The complete genomes of SD17-36 viruses of PRRSV, PCV2 and PCV3 
      were determined, which belong to the subgroups of NADC30-like PRRSV, PCV2d and 
      PCV3a respectively. Sequence comparison showed that PRRSV SD17-36 isolate 
      contains a N33 deletion in GP5. Animal challenge study showed that the novel 
      NADC30-like PRRSV SD17-36 isolate is low pathogenic. Our results indicate that 
      the co-infection of PRRSV and PCVs might cause diseases even when PRRSV plays a 
      limited role in the pathogenicity of the co-infection.
CI  - (c) 2018 Blackwell Verlag GmbH.
FAU - Chen, Nanhua
AU  - Chen N
AUID- ORCID: 0000-0002-1909-8760
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
FAU - Li, Shuai
AU  - Li S
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
FAU - Ye, Mengxue
AU  - Ye M
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
FAU - Huang, Yucheng
AU  - Huang Y
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
FAU - Huang, Ya
AU  - Huang Y
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
FAU - Xiao, Yanzhao
AU  - Xiao Y
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
FAU - Yu, Xiao
AU  - Yu X
AD  - Animal Husbandry and Veterinary Station of Jiangyan District, Taizhou, China.
FAU - Dong, Jianbao
AU  - Dong J
AUID- ORCID: 0000-0003-0424-1525
AD  - Department of Veterinary Medical Science, Shandong Vocational Animal Science and 
      Veterinary College, Weifang, China.
FAU - Tian, Kegong
AU  - Tian K
AUID- ORCID: 0000-0001-5362-1415
AD  - OIE Porcine Reproductive and Respiratory Syndrome Reference Laboratory, China 
      Animal Disease Control Center, Beijing, China.
FAU - Zhu, Jianzhong
AU  - Zhu J
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
LA  - eng
GR  - 31802172/National Natural Science Foundation of China/
GR  - BK20170492/Natural Science Foundation of Jiangsu Province/
GR  - 2016M590510/China Postdoctoral Science Foundation/
GR  - 16KJD230001/University Science Research Project of Jiangsu Province/
GR  - Jiangsu Co-innovation Center for Prevention and Control of Important Animal 
      Infectious Diseases and Zoonoses/
GR  - Priority Academic Program Development of Jiangsu Higher Education Institutions 
      (PAPD)/
PT  - Journal Article
DEP - 20181013
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
SB  - IM
MH  - Animals
MH  - Circoviridae Infections/pathology/*veterinary/virology
MH  - Circovirus/genetics/*pathogenicity
MH  - Coinfection/*veterinary/virology
MH  - Genome, Viral/genetics
MH  - Lung/virology
MH  - Lymph Nodes/virology
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*pathogenicity
MH  - Real-Time Polymerase Chain Reaction/veterinary
MH  - Sequence Analysis, DNA
MH  - Swine
MH  - Swine Diseases/*virology
MH  - Virulence
OTO - NOTNLM
OT  - NADC30-like PRRSV
OT  - co-infection
OT  - deletion in GP5
OT  - low pathogenicity
OT  - porcine circoviruses
EDAT- 2018/09/30 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/09/30 06:00
PHST- 2018/07/10 00:00 [received]
PHST- 2018/09/03 00:00 [revised]
PHST- 2018/09/20 00:00 [accepted]
PHST- 2018/09/30 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/09/30 06:00 [entrez]
AID - 10.1111/tbed.13026 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2019 Jan;66(1):28-34. doi: 10.1111/tbed.13026. Epub 2018 
      Oct 13.