PMID- 30268840
OWN - NLM
STAT- MEDLINE
DCOM- 20200131
LR  - 20200131
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 45
IP  - 4
DP  - 2019 Sep
TI  - Serum levels of osteopontin predict diabetes remission after bariatric surgery.
PG  - 356-362
LID - S1262-3636(18)30178-2 [pii]
LID - 10.1016/j.diabet.2018.09.007 [doi]
AB  - AIM: Bariatric surgery has been shown to effectively improve glycaemic control in 
      morbidly obese subjects. However, the molecular bases of this association are 
      still elusive and may act independently of weight loss. Here, our retrospective 
      study has investigated the inflammatory molecule osteopontin (OPN) as a potential 
      predictor of type 2 diabetes mellitus (T2DM) remission. METHODS: Baseline serum 
      levels of OPN were analyzed in 41 T2DM patients who underwent bariatric surgery. 
      Anthropometric measures and biochemical variables, including insulin sensitivity 
      indices (HOMA2), were assessed at baseline and at 1 and 3 years after surgery. 
      RESULTS: At baseline, patients who experienced T2DM remission had increased waist 
      circumference, body weight and BMI, and higher serum OPN, compared with 
      non-remitters. Patients with and without T2DM remission improved their lipid and 
      glucose profiles, although insulin resistance indices were only improved in the 
      T2DM remission group. In the overall cohort of both T2DM remission and 
      non-remission patients, baseline circulating levels of OPN significantly 
      correlated with reductions of body weight and BMI over time, and insulin 
      sensitivity improved as well. However, only the HOMA2-%S remained independently 
      associated with serum OPN on multivariate linear regression analysis (B: 0.227, 
      95% CI: 0.067-0.387, beta = 0.831; P = 0.010). Baseline values of OPN predicted 
      3-year T2DM remission independently of body weight loss, lower BMI and duration 
      of diabetes (OR: 1.046, 95% CI: 1.004-1.090; P = 0.033). CONCLUSION: Although 
      larger studies are still needed to confirm our preliminary results, pre-operative 
      OPN serum levels might be useful for predicting 3-year T2DM remission 
      independently of weight loss in patients undergoing bariatric surgery.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Carbone, F
AU  - Carbone F
AD  - First Clinic of Internal Medicine, Department of Internal Medicine, University of 
      Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy. Electronic address: 
      federico.carbone@edu.unige.it.
FAU - Adami, G
AU  - Adami G
AD  - Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 
      Genoa, Italy.
FAU - Liberale, L
AU  - Liberale L
AD  - First Clinic of Internal Medicine, Department of Internal Medicine, University of 
      Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; Centre for Molecular Cardiology, 
      University of Zurich, 12 Wagistrasse, 8952 Schlieren, Switzerland.
FAU - Bonaventura, A
AU  - Bonaventura A
AD  - First Clinic of Internal Medicine, Department of Internal Medicine, University of 
      Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
FAU - Bertolotto, M
AU  - Bertolotto M
AD  - First Clinic of Internal Medicine, Department of Internal Medicine, University of 
      Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
FAU - Andraghetti, G
AU  - Andraghetti G
AD  - Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 
      Genoa, Italy.
FAU - Scopinaro, N
AU  - Scopinaro N
AD  - Department of Surgery, University of Genoa, 10 Largo Benzi, 16132 Genoa, Italy.
FAU - Camerini, G B
AU  - Camerini GB
AD  - Department of Surgery, University of Genoa, 10 Largo Benzi, 16132 Genoa, Italy.
FAU - Papadia, F S
AU  - Papadia FS
AD  - Department of Surgery, University of Genoa, 10 Largo Benzi, 16132 Genoa, Italy.
FAU - Cordera, R
AU  - Cordera R
AD  - Diabetology Unit, Department of Internal Medicine, University of Genoa, 6 viale 
      Benedetto XV, 16132 Genoa, Italy.
FAU - Dallegri, F
AU  - Dallegri F
AD  - First Clinic of Internal Medicine, Department of Internal Medicine, University of 
      Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; First Clinic of Internal 
      Medicine, Ospedale Policlinico San Martino, 10 Largo Benzi, 16132, Genoa, Italy.
FAU - Montecucco, F
AU  - Montecucco F
AD  - First Clinic of Internal Medicine, Department of Internal Medicine, University of 
      Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; First Clinic of Internal 
      Medicine, Ospedale Policlinico San Martino, 10 Largo Benzi, 16132, Genoa, Italy; 
      Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 9 viale 
      Benedetto XV, 16132 Genoa, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180927
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Biomarkers)
RN  - 106441-73-0 (Osteopontin)
SB  - IM
MH  - Adult
MH  - *Bariatric Surgery
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/complications/diagnosis/*surgery
MH  - Humans
MH  - Middle Aged
MH  - Obesity/blood/complications/surgery
MH  - Osteopontin/*blood
MH  - Pilot Projects
MH  - Prognosis
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Bariatric surgery
OT  - HOMA2
OT  - Obesity
OT  - Osteopontin
OT  - Type 2 diabetes mellitus
EDAT- 2018/10/01 06:00
MHDA- 2020/02/01 06:00
CRDT- 2018/10/01 06:00
PHST- 2018/05/21 00:00 [received]
PHST- 2018/08/27 00:00 [revised]
PHST- 2018/09/15 00:00 [accepted]
PHST- 2018/10/01 06:00 [pubmed]
PHST- 2020/02/01 06:00 [medline]
PHST- 2018/10/01 06:00 [entrez]
AID - S1262-3636(18)30178-2 [pii]
AID - 10.1016/j.diabet.2018.09.007 [doi]
PST - ppublish
SO  - Diabetes Metab. 2019 Sep;45(4):356-362. doi: 10.1016/j.diabet.2018.09.007. Epub 
      2018 Sep 27.