PMID- 30269004
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20190910
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 106
DP  - 2018 Nov
TI  - The neurobiological hypothesis of neurotrophins in the pathophysiology of 
      schizophrenia: A meta-analysis.
PG  - 43-53
LID - S0022-3956(18)30593-4 [pii]
LID - 10.1016/j.jpsychires.2018.09.007 [doi]
AB  - BACKGROUND: Schizophrenia is associated with patterns of aberrant neurobiological 
      circuitry. The disease complexity is mirrored by multiple biological interactions 
      known to contribute to the disease pathology. One potential contributor is the 
      family of neurotrophins which are proteins involved in multiple functional 
      processes in the nervous system, with crucial roles in neurodevelopment, 
      synaptogenesis and neuroplasticity. With these roles in mind, abnormal 
      neurotrophin profiles have been hypothesized to contribute to the pathology of 
      schizophrenia. METHODS: We performed a systematic review and a meta-analysis to 
      scrutinize the neurobiological hypothesis of neurotrophins in schizophrenia, 
      examining the correlation between peripheral levels of brain-derived neurotrophic 
      factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin 
      4/5 (NT-4/5) associated with schizophrenia. RESULTS: Fifty-two studies were 
      reviewed and twenty-two studies were included in this meta-analysis. Using a 
      random effects model, we confirmed that decreased levels of neurotrophins (BDNF, 
      NGF and NT-4/5) were associated with schizophrenia (Hedges's g = -0.846; 
      SE = 0.058; 95% confidence interval: -0.960 to -0.733; Z-value = -14.632; 
      p-value = 0.000). Subgroup analysis indicated that neurotrophin levels are 
      significantly decreased in both medicated and drug-naive patients. 
      Meta-regression of continuous variables such as mean age, duration of illness and 
      PANSS total score did not show significant effects (p > 0.05) in relation to 
      neurotrophins levels. DISCUSSION: We confirm that decreased peripheral 
      neurotrophin levels are significantly associated with schizophrenia, thereby 
      confirming the neurobiological hypothesis of neurotrophins in schizophrenia. Low 
      levels of neurotrophins in peripheral blood of patients with schizophrenia may 
      explain, in part, the pathophysiology of schizophrenia.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Rodrigues-Amorim, Daniela
AU  - Rodrigues-Amorim D
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain.
FAU - Rivera-Baltanas, Tania
AU  - Rivera-Baltanas T
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain.
FAU - Bessa, Joao
AU  - Bessa J
AD  - Life and Health Sciences Research Institute (ICVS), School of Medicine, 
      University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate 
      Laboratory, Braga, Guimaraes, Portugal.
FAU - Sousa, Nuno
AU  - Sousa N
AD  - Life and Health Sciences Research Institute (ICVS), School of Medicine, 
      University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate 
      Laboratory, Braga, Guimaraes, Portugal.
FAU - Vallejo-Curto, Maria de Carmen
AU  - Vallejo-Curto MC
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain.
FAU - Rodriguez-Jamardo, Cynthia
AU  - Rodriguez-Jamardo C
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain.
FAU - de Las Heras, Maria Elena
AU  - de Las Heras ME
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain.
FAU - Diaz, Roberto
AU  - Diaz R
AD  - Hospital Universitari Institut Pere Mata, IISPV, URV, CIBERSAM, Reus, Spain; 
      Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Talca, Chile.
FAU - Agis-Balboa, Roberto Carlos
AU  - Agis-Balboa RC
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain.
FAU - Olivares, J M
AU  - Olivares JM
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain. Electronic address: 
      jose.manuel.olivares.diez@sergas.es.
FAU - Spuch, Carlos
AU  - Spuch C
AD  - Neuroscience Translational Group, Galicia Sur Health Research Institute, 
      SERGAS-UVIGO, CIBERSAM, Spain. Electronic address: carlos.spuch.calvar@sergas.es.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20180919
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/*blood
MH  - Schizophrenia/*blood
MH  - Young Adult
EDAT- 2018/10/01 06:00
MHDA- 2019/09/11 06:00
CRDT- 2018/10/01 06:00
PHST- 2018/05/11 00:00 [received]
PHST- 2018/09/07 00:00 [revised]
PHST- 2018/09/10 00:00 [accepted]
PHST- 2018/10/01 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
PHST- 2018/10/01 06:00 [entrez]
AID - S0022-3956(18)30593-4 [pii]
AID - 10.1016/j.jpsychires.2018.09.007 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2018 Nov;106:43-53. doi: 10.1016/j.jpsychires.2018.09.007. Epub 
      2018 Sep 19.