PMID- 30269040
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20221207
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 270
DP  - 2018 Dec
TI  - Antidepressant treatment increased serum miR-183 and miR-212 levels in patients 
      with major depressive disorder.
PG  - 232-237
LID - S0165-1781(18)30787-X [pii]
LID - 10.1016/j.psychres.2018.09.025 [doi]
AB  - Major depressive disorder (MDD) had been associated with brain-derived 
      neurotrophic factor (BDNF). Studies had shown that patients with MDD were 
      associated with lower BDNF protein levels, which could be reversed by 
      antidepressant treatment. BDNF expression had also been affected by a number of 
      microRNAs (miRNA). BDNF and miRNA in MDD had been investigated widely in the 
      recent years, but the relationships between miRNAs and antidepressants were less 
      studied. From November 2015 to October 2017, inpatients diagnosed with MDD were 
      recruited. Serum miR-16, miR-30, miR-34, miR-128, miR-132, miR-134, miR-182, 
      miR-183, miR-185, miR-212 levels were measured before and after four weeks of 
      antidepressant treatment of either selective serotonin reuptake inhibitor (SSRI) 
      or serotonin-norepinephrine reuptake inhibitor (SNRI). Thirty-three patients with 
      MDD were recruited. After treatment, miR-183 and miR-212 levels increased 
      significantly. In patients treated with SSRI (n = 13), miR-16 levels increased 
      significantly after treatment. Therefore, miR-183 and miR-212 levels increased 
      significantly after four weeks of antidepressant treatment. In the SSRI group, 
      significantly increased miR-16 levels were found, but not in SNRI group, 
      suggesting that different types of antidepressants might affect different sets of 
      miRNAs.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Lin, Chin-Chuen
AU  - Lin CC
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Tsai, Meng-Chang
AU  - Tsai MC
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Lee, Chien-Te
AU  - Lee CT
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 
      Taiwan.
FAU - Sun, Ming-Hsiang
AU  - Sun MH
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Huang, Tiao-Lai
AU  - Huang TL
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan. Electronic address: 
      a540520@adm.cgmh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180913
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (MIRN183 microRNA, human)
RN  - 0 (MIRN212 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Serotonin and Noradrenaline Reuptake Inhibitors)
SB  - IM
MH  - Adult
MH  - Depressive Disorder, Major/*blood/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood/drug effects
MH  - Middle Aged
MH  - Selective Serotonin Reuptake Inhibitors/*pharmacology
MH  - Serotonin and Noradrenaline Reuptake Inhibitors/*pharmacology
OTO - NOTNLM
OT  - Antidepressant
OT  - Major depression
OT  - MicroRNA
OT  - Selective serotonin reuptake inhibitor (SSRI)
OT  - Serotonin-norepinephrine reuptake inhibitor (SNRI)
EDAT- 2018/10/01 06:00
MHDA- 2019/04/02 06:00
CRDT- 2018/10/01 06:00
PHST- 2018/04/27 00:00 [received]
PHST- 2018/09/12 00:00 [revised]
PHST- 2018/09/12 00:00 [accepted]
PHST- 2018/10/01 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/10/01 06:00 [entrez]
AID - S0165-1781(18)30787-X [pii]
AID - 10.1016/j.psychres.2018.09.025 [doi]
PST - ppublish
SO  - Psychiatry Res. 2018 Dec;270:232-237. doi: 10.1016/j.psychres.2018.09.025. Epub 
      2018 Sep 13.