PMID- 30269521
OWN - NLM
STAT- MEDLINE
DCOM- 20200115
LR  - 20200115
IS  - 1465-3966 (Electronic)
IS  - 1354-8506 (Linking)
VI  - 24
IP  - 4
DP  - 2019 Apr
TI  - The BDNF Val66Met gene polymorphism is associated with increased alexithymic and 
      anticipatory anxiety in patients with panic disorder.
PG  - 505-511
LID - 10.1080/13548506.2018.1516890 [doi]
AB  - A large body of evidence indicates that patients with panic disorder(PD) report 
      more obvious alexithymia, and previous studies suggest genetic factors may be 
      play an important role in alexithymia. This study aims to examine the association 
      between the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 
      alexithymia, and then to evaluate the association of the BDNFVal66Met 
      polymorphism with PD risk. 223 patients with PD and 218 healthy controls were 
      enrolled in the study. The Toronto Alexithymia Scale (TAS-20), and Panic Disorder 
      Severity Scale (PDSS) were administered to all subjects. And genotyping of the 
      BDNF Val 66Met polymorphism was evaluated. Our results showed that both PD 
      patients and normal controls with the BDNF Met/Met genotype had significantly 
      higher total and difficulty describing feelings(DDF) subdimension scores on the 
      TAS-20 than those with the Val/Val genotype.The patients with the BDNF Met/Met 
      genotype were more severity of anticipatory anxiety than patients with Val/Val 
      genotype.
FAU - Zou, Zhili
AU  - Zou Z
AD  - a Department of Psychosomatic , Sichuan Provincial People's Hospital , Chengdu , 
      Sichuan , China.
FAU - Qiu, Jian
AU  - Qiu J
AD  - a Department of Psychosomatic , Sichuan Provincial People's Hospital , Chengdu , 
      Sichuan , China.
FAU - Huang, Yulan
AU  - Huang Y
AD  - a Department of Psychosomatic , Sichuan Provincial People's Hospital , Chengdu , 
      Sichuan , China.
FAU - Wang, Jinyu
AU  - Wang J
AD  - a Department of Psychosomatic , Sichuan Provincial People's Hospital , Chengdu , 
      Sichuan , China.
FAU - Min, Wenjiao
AU  - Min W
AD  - a Department of Psychosomatic , Sichuan Provincial People's Hospital , Chengdu , 
      Sichuan , China.
FAU - Zhou, Bo
AU  - Zhou B
AD  - a Department of Psychosomatic , Sichuan Provincial People's Hospital , Chengdu , 
      Sichuan , China.
LA  - eng
PT  - Journal Article
DEP - 20181001
PL  - England
TA  - Psychol Health Med
JT  - Psychology, health & medicine
JID - 9604099
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Affective Symptoms/*genetics
MH  - Anxiety/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Emotions
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Panic Disorder
MH  - *Polymorphism, Genetic
OTO - NOTNLM
OT  - BDNF Val 66Met polymorphism
OT  - China
OT  - Panic disorder
OT  - alexithymia
EDAT- 2018/10/03 06:00
MHDA- 2020/01/16 06:00
CRDT- 2018/10/02 06:00
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2020/01/16 06:00 [medline]
PHST- 2018/10/02 06:00 [entrez]
AID - 10.1080/13548506.2018.1516890 [doi]
PST - ppublish
SO  - Psychol Health Med. 2019 Apr;24(4):505-511. doi: 10.1080/13548506.2018.1516890. 
      Epub 2018 Oct 1.