PMID- 30269918
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20190122
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 36
IP  - 45
DP  - 2018 Oct 29
TI  - Tetanus-diphtheria vaccination in adults: the long-term persistence of antibodies 
      is not dependent on polyclonal B-cell activation and the defective response to 
      diphtheria toxoid re-vaccination is associated to HLADRB1 *01.
PG  - 6718-6725
LID - S0264-410X(18)31301-X [pii]
LID - 10.1016/j.vaccine.2018.09.041 [doi]
AB  - Cellular and humoral immune responses to tetanus-diphtheria vaccine (Td) were 
      assessed in human leukocyte antigen (HLA)-typed Italian military personnel who 
      received multiple concomitant vaccines. Td-specific antibodies and T-lymphocytes 
      were measured in individuals with one (group-1) and more than one (group-2) Td 
      boosters. A third group (group-3), who received several vaccines, but not Td, was 
      studied to verify the hypothesis of the polyclonal B-cell activation as mechanism 
      for antibody persistence. The antibody response to Td toxoids was higher in 
      group-1, who showed lower baseline antibody levels, than in group-2 subjects. The 
      antibody response to tetanus was higher than to diphtheria toxoid in both groups. 
      No correlation between antibody and cellular response, and no interference in the 
      response to Td by co-administration of different vaccines were observed. 
      HLA-DRB1 *01 allele was detected at significant higher frequency in subjects 
      unable to double the baseline anti-diphtheria antibody levels after the 
      vaccination. Anti-tetanus and diphtheria antibodies half-lives were assessed and 
      the long-lasting persistence above the threshold for protection (0.1 IU/ml) was 
      estimated in over 65 and 20 years, respectively. No significant increase of 
      anti-diphtheria antibodies was observed in consequence of polyclonal B-cell 
      activation. This study emphasizes the duration of Td vaccination-induced 
      seroprotection, suggesting that re-vaccination should probably be performed at 
      intervals longer than 10 years. No reciprocal interference by concomitantly 
      administered vaccines has been observed. HLA-DRB1 *01 allele was significantly 
      associated with anti-diphtheria defective response. Finally, this study does not 
      confirm that anti-diphtheria antibody levels are maintained by polyclonal B-cell 
      activation. Clinical trial registry: The study was registered with NCT01807780.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Ferlito, Claudia
AU  - Ferlito C
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Biselli, Roberto
AU  - Biselli R
AD  - Aeronautica Militare Italiana, Comando Logistico, Servizio Sanitario, Roma, 
      Italy.
FAU - Mariotti, Sabrina
AU  - Mariotti S
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy.
FAU - von Hunolstein, Christina
AU  - von Hunolstein C
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy.
FAU - Teloni, Raffaela
AU  - Teloni R
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy.
FAU - Ralli, Luisa
AU  - Ralli L
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy.
FAU - Pinto, Antonella
AU  - Pinto A
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy.
FAU - Pisani, Giulio
AU  - Pisani G
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy.
FAU - Tirelli, Valentina
AU  - Tirelli V
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy.
FAU - Biondo, Michela Ileen
AU  - Biondo MI
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Salerno, Gerardo
AU  - Salerno G
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Andreasi Bassi, Livia
AU  - Andreasi Bassi L
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Lulli, Patrizia
AU  - Lulli P
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Autore, Alberto
AU  - Autore A
AD  - Aeronautica Militare Italiana, Comando Logistico, Centro Sperimentale di Volo, 
      Pratica di Mare, Italy.
FAU - Scagliusi, Alessandro
AU  - Scagliusi A
AD  - Aeronautica Militare Italiana, Comando Logistico, Centro Sperimentale di Volo, 
      Pratica di Mare, Italy.
FAU - Tomao, Enrico
AU  - Tomao E
AD  - Aeronautica Militare Italiana, Capo del Corpo Sanitario, Roma, Italy.
FAU - Germano, Valentina
AU  - Germano V
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Picchianti Diamanti, Andrea
AU  - Picchianti Diamanti A
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Caporuscio, Sara
AU  - Caporuscio S
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Milanetti, Francesca
AU  - Milanetti F
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Salemi, Simonetta
AU  - Salemi S
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
FAU - Nisini, Roberto
AU  - Nisini R
AD  - Istituto Superiore di Sanita, Dipartimento di Malattie Infettive, Roma, Italy. 
      Electronic address: roberto.nisini@iss.it.
FAU - D'Amelio, Raffaele
AU  - D'Amelio R
AD  - Sapienza Universita di Roma, Dipartimento di Medicina Clinica e Molecolare, A.O. 
      Sant'Andrea, Roma, Italy.
LA  - eng
SI  - ClinicalTrials.gov/NCT01807780
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180927
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Diphtheria-Tetanus Vaccine)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - B-Lymphocytes/*immunology/metabolism
MH  - Diphtheria-Tetanus Vaccine/*therapeutic use
MH  - Female
MH  - Flow Cytometry
MH  - HLA Antigens/immunology/metabolism
MH  - HLA-DRB1 Chains/*metabolism
MH  - Humans
MH  - Immunization, Secondary/methods
MH  - Male
MH  - Vaccination
OTO - NOTNLM
OT  - Anti-toxoid antibodies
OT  - Duration of protection
OT  - HLA association
OT  - Memory
OT  - Vaccination
EDAT- 2018/10/03 06:00
MHDA- 2019/01/23 06:00
CRDT- 2018/10/02 06:00
PHST- 2018/05/04 00:00 [received]
PHST- 2018/09/18 00:00 [revised]
PHST- 2018/09/19 00:00 [accepted]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/10/02 06:00 [entrez]
AID - S0264-410X(18)31301-X [pii]
AID - 10.1016/j.vaccine.2018.09.041 [doi]
PST - ppublish
SO  - Vaccine. 2018 Oct 29;36(45):6718-6725. doi: 10.1016/j.vaccine.2018.09.041. Epub 
      2018 Sep 27.