PMID- 30270547 OWN - NLM STAT- MEDLINE DCOM- 20191003 LR - 20191007 IS - 1939-3806 (Electronic) IS - 1939-3806 (Linking) VI - 11 IP - 11 DP - 2018 Nov TI - Dynamic functional connectivity analysis reveals decreased variability of the default-mode network in developing autistic brain. PG - 1479-1493 LID - 10.1002/aur.2020 [doi] AB - Accumulating neuroimaging evidence suggests that abnormal functional connectivity of the default mode network (DMN) contributes to the social-cognitive deficits of autism spectrum disorder (ASD). Although most previous studies relied on conventional functional connectivity methods, which assume that connectivity patterns remain constant over time, understanding the temporal dynamics of functional connectivity during rest may provide new insights into the dysfunction of the DMN in ASD. In this work, dynamic functional connectivity analysis based on sliding time window correlation was applied to the resting-state functional magnetic resonance imaging data of 28 young children with ASD (age range: 3-7 years) and 29 matched typically developing controls (TD group). In addition, k-means cluster analysis was performed to identify distinct temporal states based on the spatial similarity of each functional connectivity pattern. Compared with the TD group, young children with ASD showed decreased dynamic functional connectivity variance between the posterior cingulate cortex (PCC) and the right precentral gyrus, which is negatively correlated with social motivation and social relating. Cluster analysis revealed significant differences in functional connectivity patterns between the ASD and TD groups in discrete temporal states. Our findings reveal that atypical dynamic interactions between the PCC and sensorimotor cortex are associated with social deficits in ASD. Results also highlight the critical role of PCC in the social-cognitive deficits of ASD and support the concept that understanding the dynamic neural interactions among brain regions can provide insights into functional abnormalities in ASD. Autism Research 2018, 11: 1479-1493. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Social cognitive dysfunction in autism spectrum disorder (ASD) is associated with dysfunction of the default mode network (DMN), a set of brain areas involved in various domains of social processing. We found that decreases in the dynamic functional connectivity variance between the posterior cingulate cortex and the sensorimotor cortex are associated with deficits in social motivation and social relating in young children with ASD. This result suggests that aberrations in the DMN and its dynamic interactions with other networks contribute to atypical integration of information with respect to self and others. CI - (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. FAU - He, Changchun AU - He C AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformaiton, University of Electronic Science and Technology of China, Chengdu, 611731, China. AD - School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. FAU - Chen, Yanchi AU - Chen Y AD - Chengdu Shishi High School, Chengdu, 610041, China. FAU - Jian, Taorong AU - Jian T AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformaiton, University of Electronic Science and Technology of China, Chengdu, 611731, China. AD - School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. FAU - Chen, Heng AU - Chen H AUID- ORCID: 0000-0001-6939-7665 AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformaiton, University of Electronic Science and Technology of China, Chengdu, 611731, China. AD - School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. FAU - Guo, Xiaonan AU - Guo X AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformaiton, University of Electronic Science and Technology of China, Chengdu, 611731, China. AD - School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. FAU - Wang, Jia AU - Wang J AD - Department of Children's and Adolescent Health, Public Health College of Harbin Medical University, Harbin, 150081, China. FAU - Wu, Lijie AU - Wu L AD - Department of Children's and Adolescent Health, Public Health College of Harbin Medical University, Harbin, 150081, China. FAU - Chen, Huafu AU - Chen H AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformaiton, University of Electronic Science and Technology of China, Chengdu, 611731, China. AD - School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. FAU - Duan, Xujun AU - Duan X AUID- ORCID: 0000-0001-8543-2117 AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformaiton, University of Electronic Science and Technology of China, Chengdu, 611731, China. AD - School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181001 PL - United States TA - Autism Res JT - Autism research : official journal of the International Society for Autism Research JID - 101461858 SB - IM MH - Autism Spectrum Disorder/*physiopathology MH - Brain/*diagnostic imaging/*physiopathology MH - Brain Mapping/*methods MH - Child MH - Child, Preschool MH - Cluster Analysis MH - Female MH - Humans MH - Magnetic Resonance Imaging/*methods MH - Male MH - Neural Pathways/diagnostic imaging/physiopathology MH - Rest OTO - NOTNLM OT - autism spectrum disorder OT - default-mode network OT - dynamic functional connectivity OT - resting-state fMRI OT - social deficits EDAT- 2018/10/03 06:00 MHDA- 2019/10/08 06:00 CRDT- 2018/10/02 06:00 PHST- 2018/03/06 00:00 [received] PHST- 2018/08/28 00:00 [accepted] PHST- 2018/10/03 06:00 [pubmed] PHST- 2019/10/08 06:00 [medline] PHST- 2018/10/02 06:00 [entrez] AID - 10.1002/aur.2020 [doi] PST - ppublish SO - Autism Res. 2018 Nov;11(11):1479-1493. doi: 10.1002/aur.2020. Epub 2018 Oct 1.