PMID- 30270667
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20200323
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 126
IP  - 2
DP  - 2020 May
TI  - Long non-coding RNA MALAT1 and microRNA-499a expression profiles in diabetic ESRD 
      patients undergoing dialysis: a preliminary cross-sectional analysis.
PG  - 172-182
LID - 10.1080/13813455.2018.1499119 [doi]
AB  - Background: Circulating non-coding RNAs (ncRNAs) have been implicated in health 
      and disease. This study aimed to evaluate the serum expression profile of 
      microRNA-499a (miR-499a) and its selected bioinformatically predicted partner 
      long-ncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) in 
      diabetes-related end-stage renal disease (ESRD) patients and to correlate the 
      expressions with the patients' clinicolaboratory data.Subjects and methods: 
      Real-time quantitative polymerase chain reaction was applied in diabetics with 
      and without ESRD (n = 90 for each).Results: Serum MALAT1 expression levels were 
      increased in the ESRD group relative to diabetics without ESRD with median 
      (quartile) values of 10.5 (1.41-126.7) (p < .001). However, miR-499a levels were 
      decreased in more than half of ESRD patients with a median of 0.96 (0.13-3.14). 
      Both MALAT1 and miR-499a expression levels were inversely correlated in the ESRD 
      patient-group.Conclusions: MALAT1 up-regulation and miR-499 down-regulation might 
      be involved in diabetic nephropathy-related ESRD pathogenesis. Functional 
      validation studies are warranted to confirm the MALAT1/miR-499a partnership.
FAU - Fawzy, Manal S
AU  - Fawzy MS
AUID- ORCID: 0000-0003-1252-8403
AD  - Department of Biochemistry, Faculty of Medicine, Northern Border University, 
      Arar, Saudi Arabia.
AD  - Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, 
      Suez Canal University, Ismailia, Egypt.
FAU - Abu AlSel, Baraah T
AU  - Abu AlSel BT
AUID- ORCID: 0000-0003-3811-0822
AD  - Department of Microbiology, Faculty of Medicine, Northern Border University, 
      Arar, Saudi Arabia.
FAU - Al Ageeli, Essam
AU  - Al Ageeli E
AUID- ORCID: 0000-0002-6625-6012
AD  - Department of Clinical Biochemistry (Medical Genetics), Faculty of Medicine, 
      Jazan University, Jazan, Saudi Arabia.
FAU - Al-Qahtani, Saeed Awad
AU  - Al-Qahtani SA
AUID- ORCID: 0000-0002-2419-2188
AD  - Department of Physiology, Faculty of Medicine, Taibah University, Almadinah 
      Almunawwarah, Saudi Arabia.
FAU - Abdel-Daim, Mohamed M
AU  - Abdel-Daim MM
AUID- ORCID: 0000-0002-4341-2713
AD  - Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal 
      University, Ismailia, Egypt.
FAU - Toraih, Eman A
AU  - Toraih EA
AUID- ORCID: 0000-0001-9267-3787
AD  - Department of Histology and Cell Biology (Genetics Unit), Faculty of Medicine, 
      Suez Canal University, Ismailia, Egypt.
AD  - Center of Excellence of Molecular and Cellular Medicine, Suez Canal University, 
      Ismailia, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180929
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (MALAT1 long non-coding RNA, human)
RN  - 0 (MIRN499 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Base Pairing
MH  - Base Sequence
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/diagnosis/*genetics/therapy
MH  - Diabetic Nephropathies/diagnosis/etiology/*genetics/therapy
MH  - Disease Progression
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Kidney Failure, Chronic/diagnosis/etiology/*genetics/therapy
MH  - Male
MH  - MicroRNAs/blood/*genetics
MH  - Middle Aged
MH  - RNA, Long Noncoding/blood/*genetics
MH  - *Renal Dialysis
OTO - NOTNLM
OT  - End-stage renal disease
OT  - MALAT1
OT  - gene expression
OT  - miR-499a
OT  - qRT-PCR
EDAT- 2018/10/03 06:00
MHDA- 2020/03/24 06:00
CRDT- 2018/10/02 06:00
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2018/10/02 06:00 [entrez]
AID - 10.1080/13813455.2018.1499119 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2020 May;126(2):172-182. doi: 
      10.1080/13813455.2018.1499119. Epub 2018 Sep 29.