PMID- 30271216
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1179-1349 (Print)
IS  - 1179-1349 (Electronic)
IS  - 1179-1349 (Linking)
VI  - 10
DP  - 2018
TI  - Accuracy of a fecal immunochemical test according to outside temperature and 
      travel time.
PG  - 1203-1213
LID - 10.2147/CLEP.S170169 [doi]
AB  - BACKGROUND: Fecal immunochemical tests (FITs) are widely used and recommended for 
      colorectal cancer (CRC) screening. Fecal hemoglobin (Hb) may degrade with long 
      transport durations and high ambient temperatures, potentially reducing 
      sensitivity to detect CRC and its precursors. This study aimed at investigating 
      the impact of temperatures and sample travel times on diagnostic performance of a 
      quantitative FIT for detection of advanced neoplasms (AN, CRC, or advanced 
      adenoma). METHODS: Participants of screening colonoscopy in south-western Germany 
      conducted a quantitative FIT prior to bowel preparation between February 2012 and 
      June 2016. From available locations and dates of stool sampling and transport, 
      maximum ambient temperatures were linked to 2,870 participants aged 50-79 years 
      and sample return durations were recorded. The impact of ambient temperatures and 
      return duration on FIT sensitivity and specificity was assessed for five 
      different cutoffs between 10 and 25 microg Hb/g feces. RESULTS: At a positivity 
      threshold of 20 microg Hb/g feces, overall sensitivity and specificity for detecting 
      any AN were 40% (95% CI, 35-47%) and 95% (95% CI, 94-96%), respectively. Inverse 
      associations between maximum ambient temperature (median 18.1 degrees C, inter-quartile 
      range [IQR] =11.4-24.9 degrees C) and sensitivity of FIT were observed which were 
      stronger at higher cutoffs. Sample return durations (median 6 days, IQR =4-8 
      days) were not associated with variable sensitivities or specificities. 
      CONCLUSION: Hb degredation during fecal sample transportation in summer months 
      may be of some concern for diagnostic performance of the FIT evaluated under 
      routine conditions in a middle-European climate.
FAU - Niedermaier, Tobias
AU  - Niedermaier T
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research 
      Center (DKFZ), Heidelberg, Germany, h.brenner@dkfz.de.
AD  - Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
FAU - Weigl, Korbinian
AU  - Weigl K
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research 
      Center (DKFZ), Heidelberg, Germany, h.brenner@dkfz.de.
AD  - Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
AD  - German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 
      Heidelberg, Germany, h.brenner@dkfz.de.
FAU - Gies, Anton
AU  - Gies A
AD  - Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
AD  - Division of Preventive Oncology, German Cancer Research Center (DKFZ) and 
      National Center for Tumor Diseases (NCT), Heidelberg, Germany, h.brenner@dkfz.de.
FAU - Hoffmeister, Michael
AU  - Hoffmeister M
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research 
      Center (DKFZ), Heidelberg, Germany, h.brenner@dkfz.de.
FAU - Brenner, Hermann
AU  - Brenner H
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research 
      Center (DKFZ), Heidelberg, Germany, h.brenner@dkfz.de.
AD  - German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 
      Heidelberg, Germany, h.brenner@dkfz.de.
AD  - Division of Preventive Oncology, German Cancer Research Center (DKFZ) and 
      National Center for Tumor Diseases (NCT), Heidelberg, Germany, h.brenner@dkfz.de.
LA  - eng
PT  - Journal Article
DEP - 20180917
PL  - New Zealand
TA  - Clin Epidemiol
JT  - Clinical epidemiology
JID - 101531700
PMC - PMC6147538
OTO - NOTNLM
OT  - advanced colorectal neoplasm
OT  - ambient temperature
OT  - fecal immunochemical test
OT  - hemoglobin degradation
OT  - sample travel time
OT  - sensitivity
COIS- Disclosure The authors declare that they received no support from any 
      organization for the submitted work; no financial relationships with any 
      organizations that might have an interest in the submitted work in the previous 
      three years; and no other relationships or activities that could appear to have 
      influenced the submitted work.
EDAT- 2018/10/03 06:00
MHDA- 2018/10/03 06:01
PMCR- 2018/09/17
CRDT- 2018/10/02 06:00
PHST- 2018/10/02 06:00 [entrez]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2018/10/03 06:01 [medline]
PHST- 2018/09/17 00:00 [pmc-release]
AID - clep-10-1203 [pii]
AID - 10.2147/CLEP.S170169 [doi]
PST - epublish
SO  - Clin Epidemiol. 2018 Sep 17;10:1203-1213. doi: 10.2147/CLEP.S170169. eCollection 
      2018.