PMID- 30271706
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240213
IS  - 2212-9588 (Print)
IS  - 2212-9596 (Electronic)
IS  - 2212-9588 (Linking)
VI  - 5
IP  - 1
DP  - 2018 Apr
TI  - THE CREATIVE PSYCHOSOCIAL GENOMIC HEALING EXPERIENCE (CPGHE) AND GENE EXPRESSION 
      IN BREAST CANCER PATIENTS: A FEASIBILITY STUDY.
PG  - 9-14
LID - 10.1016/j.aimed.2018.03.001 [doi]
AB  - BACKGROUND: Biomarkers associated with inflammation and immune function are 
      increasingly being used to examine mechanisms of the effects of mind-body 
      therapies. Less researched are biomarkers associated with cognitive and executive 
      functioning in the study of mind-body therapy mechanisms and effects. This study 
      explored the feasibility of recruiting breast cancer patients (BCPs) and 
      implementation fidelity of participation in a research project utilizing the 
      4-stage Creative Psychosocial Genomic Healing Experience (CPGHE), a mind-body 
      protocol that is theorized to create epigenetic effects via targeted 
      psychological change in emotional triggers in coping with cancer. METHODS: Eight 
      BCPs were identified as eligible (stages I, II, III, early phases of treatment) 
      and five consented to one of two intervention groups (allocated to a single 
      session or two sessions of CPGHE). Blood draws were examined pre- and post- 
      intervention for a stress/inflammation gene expression marker, Nuclear Factor 
      kappa-B (NF-kB), and three markers associated with synaptic plasticity 
      undergirding cognitive and executive functioning: Early Growth Response 1 (EGR1), 
      activity-regulated cytoskeleton-associated protein (Arc), and brain-derived 
      neurotrophic factor (BDNF). RESULTS: One consented BCP dropped out due to 
      illness. The remaining four adhered to the 4-stage CPGHE protocol and found the 
      CPGHE experience beneficial. Blood samples for the gene expression results were 
      collected and processed according to planned protocol without incident. 
      CONCLUSION: Implementing the CPGHE and achieving good adherence among a sample of 
      BCPs is feasible. Processing of blood samples collected from BCPs for gene 
      expression data is also feasible.
FAU - Munoz, Francisco V
AU  - Munoz FV
AD  - Arizona State University, College of Nursing and Health, Innovation Pomona Valley 
      Hospital Medical Center, Lewis Family, Cancer Care Center.
FAU - Larkey, Linda
AU  - Larkey L
AD  - Arizona State University, College of Nursing and Health Innovation.
LA  - eng
GR  - P20 GM103440/GM/NIGMS NIH HHS/United States
GR  - P20 RR016464/RR/NCRR NIH HHS/United States
GR  - R01 CA106370/CA/NCI NIH HHS/United States
GR  - R01 CA182901/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20180313
PL  - Netherlands
TA  - Adv Integr Med
JT  - Advances in integrative medicine
JID - 101654496
PMC - PMC6157740
MID - NIHMS951011
OTO - NOTNLM
OT  - Arc gene expression
OT  - BDNF gene expression
OT  - EGR1 (zif-268) gene expression
OT  - Mind-body therapy
OT  - NF-kB gene expression
OT  - breast cancer
OT  - stress
EDAT- 2018/10/03 06:00
MHDA- 2018/10/03 06:01
PMCR- 2019/04/01
CRDT- 2018/10/02 06:00
PHST- 2018/10/02 06:00 [entrez]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2018/10/03 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 10.1016/j.aimed.2018.03.001 [doi]
PST - ppublish
SO  - Adv Integr Med. 2018 Apr;5(1):9-14. doi: 10.1016/j.aimed.2018.03.001. Epub 2018 
      Mar 13.