PMID- 30272816
OWN - NLM
STAT- MEDLINE
DCOM- 20191231
LR  - 20191231
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 1
DP  - 2019 Jan
TI  - Remote ischemic conditioning as a cytoprotective strategy in vasculopathies 
      during hyperhomocysteinemia: An emerging research perspective.
PG  - 77-92
LID - 10.1002/jcb.27603 [doi]
AB  - Higher levels of nonprotein amino acid homocysteine (Hcy), that is, 
      hyperhomocysteinemia (HHcy) (~5% of general population) has been associated with 
      severe vasculopathies in different organs; however, precise molecular 
      mechanism(s) as to how HHcy plays havoc with body's vascular networks are largely 
      unknown. Interventional modalities have not proven beneficial to counter 
      multifactorial HHcy's effects on the vascular system. An ancient Indian form of 
      exercise called 'yoga' causes transient ischemia as a result of various body 
      postures however the cellular mechanisms are not clear. We discuss a novel 
      perspective wherein we argue that application of remote ischemic conditioning 
      (RIC) could, in fact, deliver anticipated results to patients who are suffering 
      from chronic vascular dysfunction due to HHcy. RIC is the mechanistic phenomenon 
      whereby brief episodes of ischemia-reperfusion events are applied to distant 
      tissues/organs; that could potentially offer a powerful tool in mitigating 
      chronic lethal ischemia in target organs during HHcy condition via simultaneous 
      reduction of inflammation, oxidative and endoplasmic reticulum stress, 
      extracellular matrix remodeling, fibrosis, and angiogenesis. We opine that during 
      ischemic conditioning our organs cross talk by releasing cellular messengers in 
      the form of exosomes containing messenger RNAs, circular RNAs, anti-pyroptotic 
      factors, protective cytokines like musclin, transcription factors, small 
      molecules, anti-inflammatory, antiapoptotic factors, antioxidants, and vasoactive 
      gases. All these could help mobilize the bone marrow-derived stem cells (having 
      tissue healing properties) to target organs. In that context, we argue that RIC 
      could certainly play a savior's role in an unfortunate ischemic or adverse event 
      in people who have higher levels of the circulating Hcy in their systems.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Majumder, Avisek
AU  - Majumder A
AUID- ORCID: 0000-0002-6761-2242
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky.
AD  - Department of Biochemistry and Molecular Genetics, School of Medicine, University 
      of Louisville, Louisville, Kentucky.
FAU - Singh, Mahavir
AU  - Singh M
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky.
AD  - Eye and Vision Science Laboratory, University of Louisville, Louisville, 
      Kentucky.
FAU - George, Akash K
AU  - George AK
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky.
AD  - Eye and Vision Science Laboratory, University of Louisville, Louisville, 
      Kentucky.
FAU - Homme, Rubens Petit
AU  - Homme RP
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky.
AD  - Eye and Vision Science Laboratory, University of Louisville, Louisville, 
      Kentucky.
FAU - Laha, Anwesha
AU  - Laha A
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky.
FAU - Tyagi, Suresh C
AU  - Tyagi SC
AD  - Department of Physiology, School of Medicine, University of Louisville, 
      Louisville, Kentucky.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20180911
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Cytokines)
RN  - 0 (Reactive Oxygen Species)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 2.1.1.10 (Homocysteine S-Methyltransferase)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Endoplasmic Reticulum Stress
MH  - Homocysteine/*metabolism
MH  - Homocysteine S-Methyltransferase/metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*metabolism/*therapy
MH  - Inflammation/metabolism
MH  - Ischemia/metabolism
MH  - Mesenchymal Stem Cells/metabolism
MH  - Mice
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Reperfusion/*methods
MH  - Vascular Diseases/complications/*metabolism/*therapy
OTO - NOTNLM
OT  - cardio protection
OT  - inflammation
OT  - ischemia
OT  - ischemic preconditioning
OT  - oxidative stress
EDAT- 2018/10/03 06:00
MHDA- 2020/01/01 06:00
CRDT- 2018/10/02 06:00
PHST- 2018/04/18 00:00 [received]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2020/01/01 06:00 [medline]
PHST- 2018/10/02 06:00 [entrez]
AID - 10.1002/jcb.27603 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 Jan;120(1):77-92. doi: 10.1002/jcb.27603. Epub 2018 Sep 11.