PMID- 30273985
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20210109
IS  - 2162-3279 (Electronic)
VI  - 8
IP  - 11
DP  - 2018 Nov
TI  - Effect of electroconvulsive therapy on brain-derived neurotrophic factor levels 
      in patients with major depressive disorder.
PG  - e01101
LID - 10.1002/brb3.1101 [doi]
LID - e01101
AB  - OBJECTIVES: Brain-derived neurotrophic factor (BDNF) has been associated with 
      depression and its treatment response. The aim of the present study was to 
      explore the effect of electroconvulsive therapy (ECT) on serum and plasma BDNF 
      levels and change of Montgomery-Asberg Depression Rating Scale (MADRS) and their 
      associations in patients with major depressive disorder (MDD). METHODS: The study 
      included thirty patients suffering from MDD. Their serum and plasma BDNF levels 
      were examined before ECT (baseline) and after the first, fifth, and last ECT 
      session. The severity of the depression and the response to ECT were measured 
      with MADRS. RESULTS: Electroconvulsive therapy caused no significant changes in 
      serum BDNF levels. Plasma BDNF levels decreased during the fifth ECT session 
      between the baseline and the 2-hr samples (p = 0.019). No associations were found 
      between serum or plasma BDNF levels and remission. The correlations between 
      plasma and serum BDNF levels in each measurement varied between 0.187 and 0.636. 
      CONCLUSIONS: Neither serum nor plasma BDNF levels were systematically associated 
      with the clinical remission. However, the plasma BDNF levels somewhat varied 
      during the ECT series. Therefore, the predictive value of BDNF for effects of ECT 
      appears to be at least modest.
CI  - (c) 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
FAU - Sorri, Annamari
AU  - Sorri A
AUID- ORCID: 0000-0002-3565-2805
AD  - Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
AD  - Department of Psychiatry, School of Medicine, University of Tampere, Tampere, 
      Finland.
FAU - Jarventausta, Kaija
AU  - Jarventausta K
AD  - Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
AD  - Department of Psychiatry, School of Medicine, University of Tampere, Tampere, 
      Finland.
FAU - Kampman, Olli
AU  - Kampman O
AD  - Department of Psychiatry, School of Medicine, University of Tampere, Tampere, 
      Finland.
AD  - Department of Psychiatry, Seinajoki Hospital District, Seinajoki, Finland.
FAU - Lehtimaki, Kai
AU  - Lehtimaki K
AD  - Department of Neurosurgery, Neurology and Rehabilitation, Tampere University 
      Hospital, Tampere, Finland.
FAU - Bjorkqvist, Minna
AU  - Bjorkqvist M
AD  - Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
FAU - Tuohimaa, Kati
AU  - Tuohimaa K
AD  - Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
FAU - Hamalainen, Mari
AU  - Hamalainen M
AD  - The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, 
      University of Tampere and Tampere University Hospital, Tampere, Finland.
FAU - Moilanen, Eeva
AU  - Moilanen E
AD  - The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, 
      University of Tampere and Tampere University Hospital, Tampere, Finland.
FAU - Leinonen, Esa
AU  - Leinonen E
AD  - Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
AD  - Department of Psychiatry, School of Medicine, University of Tampere, Tampere, 
      Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181001
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depressive Disorder, Major/blood/*therapy
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
PMC - PMC6236235
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - electroconvulsive therapy
OT  - major depressive disorder
OT  - neurotrophin
EDAT- 2018/10/03 06:00
MHDA- 2019/07/16 06:00
PMCR- 2018/10/01
CRDT- 2018/10/02 06:00
PHST- 2018/04/18 00:00 [received]
PHST- 2018/06/28 00:00 [revised]
PHST- 2018/07/15 00:00 [accepted]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2018/10/02 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - BRB31101 [pii]
AID - 10.1002/brb3.1101 [doi]
PST - ppublish
SO  - Brain Behav. 2018 Nov;8(11):e01101. doi: 10.1002/brb3.1101. Epub 2018 Oct 1.