PMID- 30274621
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20211204
IS  - 1558-3163 (Electronic)
IS  - 0889-857X (Linking)
VI  - 44
IP  - 4
DP  - 2018 Nov
TI  - Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
PG  - 525-543
LID - S0889-857X(18)30054-1 [pii]
LID - 10.1016/j.rdc.2018.06.001 [doi]
AB  - Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is the most 
      common cause of rapidly progressive glomerulonephritis. ANCAs play an important 
      role in the pathogenesis and diagnosis of AAV. The classic renal lesion in AAV is 
      a pauci-immune necrotizing and crescentic glomerulonephritis. Treatment is 
      divided into 2 phases: (1) induction of remission to eliminate disease activity 
      and (2) maintenance of remission to prevent disease relapse. AAV patients with 
      end-stage renal disease require modification of immunosuppressive strategies and 
      consideration for kidney transplantation. An improved understanding of disease 
      pathogenesis has led to new treatment strategies being tested in clinical trials.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Zonozi, Reza
AU  - Zonozi R
AD  - Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts 
      General Hospital, 101 Merrimac Street, Boston, MA 02114, USA.
FAU - Niles, John L
AU  - Niles JL
AD  - Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts 
      General Hospital, 101 Merrimac Street, Boston, MA 02114, USA.
FAU - Cortazar, Frank B
AU  - Cortazar FB
AD  - Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts 
      General Hospital, 101 Merrimac Street, Boston, MA 02114, USA. Electronic address: 
      FCORTAZAR@PARTNERS.ORG.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180907
PL  - United States
TA  - Rheum Dis Clin North Am
JT  - Rheumatic diseases clinics of North America
JID - 8708093
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/immunology
MH  - Antibodies, Antineutrophil Cytoplasmic/blood
MH  - Disease Progression
MH  - *Glomerulonephritis/diagnosis/etiology
MH  - Humans
MH  - Immunosuppression Therapy/*methods
MH  - Prognosis
MH  - Secondary Prevention
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - Granulomatosis with polyangiitis
OT  - Microscopic polyangiitis
OT  - Rapidly progressive glomerulonephritis
EDAT- 2018/10/03 06:00
MHDA- 2019/01/29 06:00
CRDT- 2018/10/03 06:00
PHST- 2018/10/03 06:00 [entrez]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
AID - S0889-857X(18)30054-1 [pii]
AID - 10.1016/j.rdc.2018.06.001 [doi]
PST - ppublish
SO  - Rheum Dis Clin North Am. 2018 Nov;44(4):525-543. doi: 10.1016/j.rdc.2018.06.001. 
      Epub 2018 Sep 7.