PMID- 30276171
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 14
IP  - 4
DP  - 2018 Aug
TI  - The combined impacts of docosahexaenoic acid, endurance physical exercise, and 
      prolonged fasting on brain function.
PG  - 540-544
LID - 10.12965/jer.1836298.149 [doi]
AB  - Docosahexaenoic acid (DHA), a long chain polyunsaturated fatty acid (PUFA) is 
      highly enriched in the membrane phospholipids of the brain, neuronal tissue and 
      retina. Accumulating evidence suggests that brain DHA is necessary for 
      maintaining for optimal function of the cognition and the visual system, 
      particularly the photoreceptor, the retina. Loss of brain DHA, especially during 
      crucial brain development period, was highly associated with visual and cognitive 
      defects. Here it would be addressed the effect of DHA on brain functions as 
      assessed by spatial task performance using a first generation model which is 
      similar to human nutrition case. And also, it was well known that prolonged 
      fasting and energy restriction with endurance physical exercise stimulate 
      cognitive function and brain function, which is caused by upregulated ketone body 
      and upregulated brain-derived neurotropic factor (BDNF) responses. In the DHA 
      intake or prolonged physical exercise, upregulated BDNF can activate 
      mitochondrial biogenesis to elevate neuronal bioenergetics and enable synaptic 
      formation. And it also can activate DNA repair in neurons. Further study on the 
      mechanisms about the combine effects of supplementation of DHA and energy 
      restriction on brain function is urgently needed in this area.
FAU - Kwak, Yi-Sub
AU  - Kwak YS
AD  - Department of Physical Education, College of Arts, Design and Sports Science, 
      Dong-Eui University, Busan, Korea.
FAU - Lim, Sun Young
AU  - Lim SY
AUID- ORCID: 0000-0002-8091-3496
AD  - Division of Marine Bioscience, Korea Maritime and Ocean University, Busan, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180824
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC6165984
OTO - NOTNLM
OT  - Brain function
OT  - Brain-derived neurotropic factor
OT  - Docosahexaenoic acid
OT  - Endurance physical exercise
OT  - N-3 fatty acid deficiency
OT  - Prolonged fasting
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2018/10/03 06:00
MHDA- 2018/10/03 06:01
PMCR- 2018/08/24
CRDT- 2018/10/03 06:00
PHST- 2018/06/11 00:00 [received]
PHST- 2018/07/23 00:00 [accepted]
PHST- 2018/10/03 06:00 [entrez]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2018/10/03 06:01 [medline]
PHST- 2018/08/24 00:00 [pmc-release]
AID - jer-14-4-540 [pii]
AID - 10.12965/jer.1836298.149 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2018 Aug 24;14(4):540-544. doi: 10.12965/jer.1836298.149. 
      eCollection 2018 Aug.