PMID- 30276890
OWN - NLM
STAT- MEDLINE
DCOM- 20200807
LR  - 20200807
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 50
IP  - 3
DP  - 2019 Aug
TI  - Role of NMDA and AMPA glutamatergic receptors in the effects of social defeat on 
      the rewarding properties of MDMA in mice.
PG  - 2623-2634
LID - 10.1111/ejn.14190 [doi]
AB  - Exposure to social stress alters the response to drugs of abuse of experimental 
      animals. Changes in the glutamatergic system seem to play a role in the effects 
      of social defeat stress on the rewarding properties of cocaine and amphetamine. 
      The aim of the present study was to evaluate the involvement of 
      N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic 
      acid (AMPA) glutamate receptors in the effects of social defeat on the 
      conditioned place preference induced by 3,4-methylenedioxymethamphetamine (MDMA). 
      Our hypothesis was that changes in these receptors could mediate the effects of 
      social defeat on MDMA reward. Young adult male mice were exposed to an episode of 
      social defeat with an aggressive conspecific immediately before each conditioning 
      session with MDMA (1.25 mg/kg, four sessions on alternating days). According to 
      the treatment received before defeats, six groups were used: saline, 5 or 
      10 mg/kg of memantine (NMDA antagonist) and 0.25, 1 or 5 mg/kg of 
      6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (AMPA antagonist). One control group 
      was exposed to exploration before place conditioning. In two additional defeated 
      and control groups, the membrane expression of NMDA and AMPA receptors was 
      determined in the striatum and the hippocampus. Control and memantine-treated 
      groups developed place preference, but not defeated mice treated with saline or 
      CNQX, suggesting that the blockade of NMDA receptors reversed the effects of 
      social defeat. Social defeat decreased the expression of several subunits of NMDA 
      and AMPA receptors, mainly GluN1 and GluA1. These results demonstrated that 
      glutamatergic plasticity is involved in the effects of social defeat stress on 
      MDMA reward.
CI  - (c) 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Garcia-Pardo, M P
AU  - Garcia-Pardo MP
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Avda. Blasco 
      Ibanez, 21, 46010, Valencia, Spain.
AD  - Unitat Predepartamental de Medicina, Facultat de Ciencies de la Salut, 
      Universitat Jaume I. Castello de la Plana, Castello, Spain.
FAU - Minarro, J
AU  - Minarro J
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Avda. Blasco 
      Ibanez, 21, 46010, Valencia, Spain.
FAU - Llansola, M
AU  - Llansola M
AD  - Laboratory of Neurobiology, Centro Investigacion Principe Felipe, Valencia, 
      Spain.
FAU - Felipo, V
AU  - Felipo V
AD  - Laboratory of Neurobiology, Centro Investigacion Principe Felipe, Valencia, 
      Spain.
FAU - Aguilar, M A
AU  - Aguilar MA
AUID- ORCID: 0000-0002-1935-6619
AD  - Unidad de Investigacion Psicobiologia de las Drogodependencias, Departamento de 
      Psicobiologia, Facultad de Psicologia, Universidad de Valencia, Avda. Blasco 
      Ibanez, 21, 46010, Valencia, Spain.
LA  - eng
GR  - PSI2014-51847-R/Ministerio de Economia y Competitividad (MINECO)/International
GR  - PSI2017-83023 (AEI/FEDER, UE)/Ministerio de Ciencia, Innovacion y 
      Universidades/International
GR  - Instituto de Salud Carlos III/International
GR  - RD16/0017/0007/Red de Trastornos Adictivos (RTA)/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181024
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/pharmacology
MH  - Animals
MH  - Conditioning, Psychological/drug effects/physiology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Receptors, AMPA/antagonists & inhibitors/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
MH  - *Reward
MH  - *Social Behavior
MH  - Stress, Psychological/*metabolism/psychology
OTO - NOTNLM
OT  - conditioned place preference
OT  - drug addiction
OT  - glutamate receptor
OT  - stress
EDAT- 2018/10/03 06:00
MHDA- 2020/08/08 06:00
CRDT- 2018/10/03 06:00
PHST- 2018/03/20 00:00 [received]
PHST- 2018/09/14 00:00 [revised]
PHST- 2018/09/20 00:00 [accepted]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2020/08/08 06:00 [medline]
PHST- 2018/10/03 06:00 [entrez]
AID - 10.1111/ejn.14190 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2019 Aug;50(3):2623-2634. doi: 10.1111/ejn.14190. Epub 2018 Oct 
      24.