PMID- 30276909
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 1521-3927 (Electronic)
IS  - 1022-1336 (Linking)
VI  - 39
IP  - 24
DP  - 2018 Dec
TI  - UV Light-Responsive Peptide-Based Supramolecular Hydrogel for Controlled Drug 
      Delivery.
PG  - e1800588
LID - 10.1002/marc.201800588 [doi]
AB  - Low-molecular-weight self-assembled peptides may serve as promising hydrogelators 
      for drug delivery applications by changing their structural network in response 
      to external stimuli. Herein, inspired by the well-studied low-molecular-weight 
      peptide hydrogelator, fluorenyl-methoxycarbonyl-diphenylalanine (Fmoc-FF), a 
      novel peptide is designed and synthesized to include an ultraviolet 
      (UV)-sensitive phototrigger. Similar to Fmoc-FF, 
      6-nitroveratryloxycarbonyl-diphenylalanine (Nvoc-FF) self-assembles to form a 3D, 
      self-supporting, nanofibrous hydrogel. The Nvoc-FF hydrogel exhibits good 
      mechanical properties with a storage modulus of 40 kPa. UV irradiation of the 
      Nvoc-FF hydrogel encapsulating insulin-fluorescein isothiocyanate (insulin-FITC) 
      results in the cleavage of Nvoc-FF peptide to produce unmasked FF, thereby 
      facilitating the degradation of the hydrogel and the release of insulin-FITC. 
      This release is in linear correlation to the irradiation time. In the present 
      study, a first insight into this rigid, fibrous, light-responsive hydrogel is 
      provided, allowing the fabrication of a novel drug delivery system for controlled 
      release of large molecules.
CI  - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Roth-Konforti, Michal E
AU  - Roth-Konforti ME
AD  - School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 
      69978, Israel.
FAU - Comune, Michela
AU  - Comune M
AUID- ORCID: 0000-0003-0835-7832
AD  - Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler 
      Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
FAU - Halperin-Sternfeld, Michal
AU  - Halperin-Sternfeld M
AD  - Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler 
      Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
FAU - Grigoriants, Irena
AU  - Grigoriants I
AD  - Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler 
      Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
FAU - Shabat, Doron
AU  - Shabat D
AD  - School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 
      69978, Israel.
FAU - Adler-Abramovich, Lihi
AU  - Adler-Abramovich L
AUID- ORCID: 0000-0003-3433-0625
AD  - Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler 
      Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
LA  - eng
GR  - 1732/17/Israel Science Foundation/
PT  - Journal Article
DEP - 20181001
PL  - Germany
TA  - Macromol Rapid Commun
JT  - Macromolecular rapid communications
JID - 9888239
RN  - 0 (Hydrogels)
RN  - 0 (Insulin)
RN  - 0 (Isothiocyanates)
RN  - 0 (Peptides)
RN  - 3129-90-6 (isothiocyanic acid)
RN  - I223NX31W9 (Fluorescein-5-isothiocyanate)
SB  - IM
MH  - Drug Delivery Systems/*methods
MH  - Fluorescein-5-isothiocyanate/chemistry
MH  - Hydrogels/*chemistry
MH  - Insulin/chemistry
MH  - Isothiocyanates/chemistry
MH  - Peptides/*chemistry
MH  - *Ultraviolet Rays
OTO - NOTNLM
OT  - drug delivery
OT  - hydrogels
OT  - low-molecular-weight hydrogelators
OT  - peptides
OT  - photo-responsive
EDAT- 2018/10/03 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/10/03 06:00
PHST- 2018/08/04 00:00 [received]
PHST- 2018/09/08 00:00 [revised]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/10/03 06:00 [entrez]
AID - 10.1002/marc.201800588 [doi]
PST - ppublish
SO  - Macromol Rapid Commun. 2018 Dec;39(24):e1800588. doi: 10.1002/marc.201800588. 
      Epub 2018 Oct 1.