PMID- 30276946
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20190808
IS  - 1479-8301 (Electronic)
IS  - 1346-3500 (Linking)
VI  - 19
IP  - 2
DP  - 2019 Mar
TI  - Decreased perfusion of the posterior cingulate gyri shown by a cingulate island 
      score is a possible marker of vulnerability to behavioural and psychological 
      symptoms of Alzheimer's disease: a pilot study.
PG  - 165-170
LID - 10.1111/psyg.12379 [doi]
AB  - BACKGROUND: The cingulate island score (CIScore), which indicates the Z-score 
      ratio of the posterior cingulate gyri to the medial occipital area, has been 
      shown to be useful for differentiating dementia with Lewy bodies from Alzheimer's 
      disease (AD). Our aim was to investigate associations between the clinical 
      symptoms of AD and the CIScore as an index of the relative decrease in perfusion 
      of the posterior cingulate gyri that occurs in the early stages of AD. METHODS: 
      Seventeen patients with early-stage AD and 13 patients with amnesic mild 
      cognitive impairment were examined. Z-score maps of technetium-99m ethyl 
      cysteinate dimer single-photon emission computed tomography images acquired from 
      the patients were converted, and the CIScore was determined by using the easy 
      Z-score imaging system. The relationships between the CIScore and clinical 
      symptom scores were tested. RESULTS: A significant correlation was identified 
      between the CIScore and the Neuropsychiatric Inventory Questionnaire score. No 
      significant correlations were identified between the CIScore and other measures 
      of cognitive function. Based on a CIScore of 0.39, we correctly differentiated 
      patients with and without behavioural and psychological symptoms of dementia 
      (BPSD), with a sensitivity of 72.2% and specificity of 75.0%. DISCUSSION: Using 
      technetium-99m ethyl cysteinate dimer single-photon emission computed tomography, 
      we observed that decreased posterior cingulate gyri perfusion, relative to the 
      medial occipital area, in prodromal and early AD was closely associated with 
      behavioural and psychological symptoms of dementia. Therefore, our findings 
      suggest that CIScore is not only useful for discriminating dementia with Lewy 
      bodies from AD, but it can also be clinically used as a specific indicator of the 
      vulnerability to behavioural and psychological symptoms of dementia in the early 
      stages of AD.
CI  - (c) 2018 Japanese Psychogeriatric Society.
FAU - Yasuno, Fumihiko
AU  - Yasuno F
AUID- ORCID: 0000-0002-5981-5795
AD  - Department of Psychiatry, Nara Medical University, Kashihara, Japan.
AD  - Department of Psychiatry, National Center for Geriatrics and Gerontology, Obu, 
      Japan.
FAU - Matsuoka, Kiwamu
AU  - Matsuoka K
AD  - Department of Psychiatry, Nara Medical University, Kashihara, Japan.
FAU - Miyasaka, Toshiteru
AU  - Miyasaka T
AD  - Department of Radiology, Nara Medical University, Kashihara, Japan.
FAU - Takahashi, Masato
AU  - Takahashi M
AD  - Department of Psychiatry, Nara Medical University, Kashihara, Japan.
FAU - Kitamura, Soichiro
AU  - Kitamura S
AD  - Department of Psychiatry, Nara Medical University, Kashihara, Japan.
FAU - Yoshikawa, Hiroaki
AU  - Yoshikawa H
AD  - Department of Psychiatry, Nara Medical University, Kashihara, Japan.
FAU - Hattori, Hideyuki
AU  - Hattori H
AD  - Department of Psychiatry, National Center for Geriatrics and Gerontology, Obu, 
      Japan.
FAU - Kichikawa, Kimihiko
AU  - Kichikawa K
AD  - Department of Radiology, Nara Medical University, Kashihara, Japan.
FAU - Kishimoto, Toshifumi
AU  - Kishimoto T
AD  - Department of Psychiatry, Nara Medical University, Kashihara, Japan.
LA  - eng
GR  - Grants-in-Aid for Scientific Research (C) 15K0984/Japan Society for the Promotion 
      of Science/
GR  - Nara Medical University/
PT  - Journal Article
DEP - 20181001
PL  - England
TA  - Psychogeriatrics
JT  - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
JID - 101230058
RN  - 0 (Radiopharmaceuticals)
RN  - 7440-26-8 (Technetium)
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*diagnosis/*physiopathology/psychology
MH  - Cognitive Dysfunction/diagnosis/physiopathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Gyrus Cinguli/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Technetium
MH  - Tomography, Emission-Computed, Single-Photon
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - SPECT
OT  - cognitive dysfunction
OT  - dementia with Lewy bodies
OT  - posterior cingulate gyrus
EDAT- 2018/10/03 06:00
MHDA- 2019/08/09 06:00
CRDT- 2018/10/03 06:00
PHST- 2018/07/24 00:00 [received]
PHST- 2018/08/15 00:00 [revised]
PHST- 2018/08/27 00:00 [accepted]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
PHST- 2018/10/03 06:00 [entrez]
AID - 10.1111/psyg.12379 [doi]
PST - ppublish
SO  - Psychogeriatrics. 2019 Mar;19(2):165-170. doi: 10.1111/psyg.12379. Epub 2018 Oct 
      1.