PMID- 30277207
OWN - NLM
STAT- MEDLINE
DCOM- 20190912
LR  - 20200309
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 99
IP  - 6
DP  - 2018 Dec
TI  - Case Report: Strongyloides stercoralis Hyperinfection in a Patient with HTLV-1: 
      An Infection with Filariform and Rhabditiform Larvae, Eggs, and Free-Living Adult 
      Females Output.
PG  - 1583-1586
LID - 10.4269/ajtmh.18-0402 [doi]
AB  - Strongyloides stercoralis is the main etiological agent of human 
      strongyloidiasis. Severe strongyloidiasis is commonly associated to alcoholism, 
      corticostereoid use, and human T cell lymphotropic virus type 1 (HTLV-1) 
      coinfection. Herein, we report a case of a 13-year-old boy coinfected with S. 
      stercoralis and HTLV-1, excreting several parasitic forms in the stool. The 
      parasitological examination of his feces showed a large amount of filariform 
      (about 3,000 larvae per gram of feces) and rhabditiform larvae (about 2,000 
      larvae per gram of feces). In addition, free-living adult females (about 50 
      parasites per gram of feces) and eggs (about 60 eggs per gram of feces) were 
      detected. The main laboratory findings pointed to high immunoglobulin E (IgE) 
      levels (228 UI/mL) and eosinophila (11.6%). The patient was treated with three 
      courses of ivermectin (200 microg/kg twice, 2 weeks apart), achieving the 
      parasitological cure. An increase of about 19 times in interleucin (IL)-17 level 
      was observed following the parasitological cure, in addition to a decrease in the 
      white blood cell, eosinophil counts, and IgE levels. This is the first case 
      report, to our knowledge, in which an S. stercoralis adult free-living female was 
      described in human feces and where an increase in IL-17 levels after 
      Strongyloides treatment in a HTLV-1 coinfected individual was observed. This 
      finding raises the need for further studies about IL-17 immunomodulation in S. 
      stercoralis and HTLV-1 coinfected patients.
FAU - De Souza, Joelma Nascimento
AU  - De Souza JN
AD  - Faculdade de Farmacia, Universidade Federal da Bahia (UFBA), Salvador, Brazil.
FAU - Soares, Barbara Nascimento Rocha Ribeiro
AU  - Soares BNRR
AD  - Laboratorio de Saude Publica (LASP), Centro de Pesquisas Goncalo Moniz (Fiocruz), 
      Salvador, Brazil.
FAU - Goes, Luana Leandro
AU  - Goes LL
AD  - Laboratorio de Saude Publica (LASP), Centro de Pesquisas Goncalo Moniz (Fiocruz), 
      Salvador, Brazil.
FAU - Lima, Cintia de Souza
AU  - Lima CS
AD  - Faculdade de Farmacia, Universidade Federal da Bahia (UFBA), Salvador, Brazil.
FAU - Barreto, Nilo Manoel Pereira Vieira
AU  - Barreto NMPV
AD  - Faculdade de Farmacia, Universidade Federal da Bahia (UFBA), Salvador, Brazil.
FAU - Jacobina, Beatriz Soares
AU  - Jacobina BS
AD  - Centro Integrativo e Multidisciplinar de Atendimento ao Portador de HTLV da, 
      Escola Bahiana de Medicina e Saude Publica (CHTLV/EBMSP), Salvador, Brazil.
FAU - Goncalves, Noilson
AU  - Goncalves N
AD  - Centro Integrativo e Multidisciplinar de Atendimento ao Portador de HTLV da, 
      Escola Bahiana de Medicina e Saude Publica (CHTLV/EBMSP), Salvador, Brazil.
FAU - Teixeira, Marcia Cristina Aquino
AU  - Teixeira MCA
AD  - Faculdade de Farmacia, Universidade Federal da Bahia (UFBA), Salvador, Brazil.
FAU - Galvao-Castro, Bernardo
AU  - Galvao-Castro B
AD  - Centro Integrativo e Multidisciplinar de Atendimento ao Portador de HTLV da, 
      Escola Bahiana de Medicina e Saude Publica (CHTLV/EBMSP), Salvador, Brazil.
FAU - Grassi, Maria Fernanda Rios
AU  - Grassi MFR
AD  - Centro Integrativo e Multidisciplinar de Atendimento ao Portador de HTLV da, 
      Escola Bahiana de Medicina e Saude Publica (CHTLV/EBMSP), Salvador, Brazil.
FAU - Soares, Neci Matos
AU  - Soares NM
AD  - Faculdade de Farmacia, Universidade Federal da Bahia (UFBA), Salvador, Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180927
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Anthelmintics)
RN  - 0 (Interleukin-17)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 70288-86-7 (Ivermectin)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Anthelmintics/therapeutic use
MH  - Brazil
MH  - Coinfection
MH  - Feces/*parasitology
MH  - Female
MH  - HTLV-I Infections/*diagnosis/immunology/pathology
MH  - Human T-lymphotropic virus 1/*immunology/isolation & purification
MH  - Humans
MH  - Immunoglobulin E/biosynthesis
MH  - Interleukin-17/biosynthesis
MH  - Ivermectin/therapeutic use
MH  - Larva/immunology
MH  - Male
MH  - Parasite Egg Count
MH  - Strongyloides stercoralis/*immunology/isolation & purification
MH  - Strongyloidiasis/*diagnosis/drug therapy/immunology/pathology
MH  - Zygote/immunology
PMC - PMC6283480
EDAT- 2018/10/03 06:00
MHDA- 2019/09/13 06:00
PMCR- 2019/12/01
CRDT- 2018/10/03 06:00
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2019/09/13 06:00 [medline]
PHST- 2018/10/03 06:00 [entrez]
PHST- 2019/12/01 00:00 [pmc-release]
AID - tpmd180402 [pii]
AID - 10.4269/ajtmh.18-0402 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2018 Dec;99(6):1583-1586. doi: 10.4269/ajtmh.18-0402. Epub 
      2018 Sep 27.