PMID- 30277684
OWN - NLM
STAT- MEDLINE
DCOM- 20181219
LR  - 20181219
IS  - 0387-5911 (Print)
IS  - 0387-5911 (Linking)
VI  - 91
IP  - 1
DP  - 2017 Jan
TI  - [Successful Treatment of Immune Reconstitution Inflammatory Syndrome with 
      Corticosteroid for Patient with Kaposi's Sarcoma Extending into the Respiratory 
      Tract and Both Lungs].
PG  - 25-30
AB  - An HIV-infected man in his 30s was transferred to our hospital after the 
      discontinuation of antiretroviral therapy (ART) for 4 years. An intraoral tumor 
      was identified, and a biopsy was performed. The diagnosis was Kaposi's sarcoma 
      (KS) and disseminated lesions were detected in his respiratory tract and both 
      lungs on computed tomography (CT) and 2-[18F] fluoro-2-deoxy-D-glucose 
      positron-emission tomography (FDG/PET) imaging with increasing standardized 
      uptake volume (SUV: max 7.4). On the 7th day, he was intubated to maintain his 
      airway, then antiretroviral therapy and chemotherapy with pegylated liposomal 
      doxorubicin were immediately initiated. After a period of remission, pulmonary 
      lesions were detected again. We regarded them as a manifestation of immune 
      reconstitution inflammatory syndrome (IRIS) and gave him short term 
      corticosteroids. The lesions were then successfully controlled without additional 
      chemotherapy. This case suggests that early induction of ART and intensive care 
      can result in the survival of patients with KS having serious stenosis of the 
      respiratory tract. Furthermore, this presenting case suggested that the use of 
      corticosteroids could be a candidate to control IRIS even in patients with 
      Kaposi's sarcoma.
FAU - Shikawa, Tetsuya
AU  - Shikawa T
FAU - Yanagisawa, Kunio
AU  - Yanagisawa K
FAU - Ogawa, Yoshiyuki
AU  - Ogawa Y
FAU - Uchiumi, Hideki
AU  - Uchiumi H
FAU - Gohda, Fumito
AU  - Gohda F
FAU - Handa, Hiroshi
AU  - Handa H
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Kansenshogaku Zasshi
JT  - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious 
      Diseases
JID - 0236671
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Adult
MH  - HIV Infections/*complications
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*drug therapy/*etiology
MH  - Lung Diseases/*drug therapy/etiology
MH  - Male
MH  - Respiratory Tract Diseases/*drug therapy/etiology
MH  - Sarcoma, Kaposi/*etiology
EDAT- 2017/01/01 00:00
MHDA- 2018/12/20 06:00
CRDT- 2018/10/03 06:00
PHST- 2018/10/03 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2018/12/20 06:00 [medline]
PST - ppublish
SO  - Kansenshogaku Zasshi. 2017 Jan;91(1):25-30.