PMID- 30278186
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20190408
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 91
DP  - 2019 Feb
TI  - Transgenerational plasticity and antiviral immunity in the Pacific oyster 
      (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1).
PG  - 17-25
LID - S0145-305X(18)30349-5 [pii]
LID - 10.1016/j.dci.2018.09.022 [doi]
AB  - The oyster's immune system is capable of adapting upon exposure to a 
      pathogen-associated molecular pattern (PAMP) to have an enhanced secondary 
      response against the same type of pathogen. This has been demonstrated using 
      poly(I:C) to elicit an antiviral response in the Pacific oyster (Crassostrea 
      gigas) against Ostreid herpesvirus (OsHV-1). Improved survival following exposure 
      to poly(I:C) has been found in later life stages (within-generational immune 
      priming) and in the next generation (transgenerational immune priming). The 
      mechanism that the oyster uses to transfer immunity to the next generation is 
      unknown. Here we show that oyster larvae have higher survival to OsHV-1 when 
      their mothers, but not their fathers, are exposed to poly(I:C) prior to spawning. 
      RNA-seq provided no evidence to suggest that parental exposure to poly(I:C) 
      reconfigures antiviral gene expression in unchallenged larvae. We conclude that 
      the improved survival of larvae might occur via maternal provisioning of 
      antiviral compounds in the eggs.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Lafont, Maxime
AU  - Lafont M
AD  - Sydney Institute of Marine Science, Chowder Bay, Sydney, Australia; IHPE, 
      Universite de Montpellier, CNRS, Ifremer, Universite de Perpignan Via Domitia, 
      France.
FAU - Goncalves, Priscila
AU  - Goncalves P
AD  - Sydney Institute of Marine Science, Chowder Bay, Sydney, Australia; Macquarie 
      University, Department of Biological Sciences, Sydney, Australia.
FAU - Guo, Ximing
AU  - Guo X
AD  - Haskin Shellfish Research Laboratory, Rutgers University, Port Norris, NJ, USA.
FAU - Montagnani, Caroline
AU  - Montagnani C
AD  - IHPE, Universite de Montpellier, CNRS, Ifremer, Universite de Perpignan Via 
      Domitia, France.
FAU - Raftos, David
AU  - Raftos D
AD  - Sydney Institute of Marine Science, Chowder Bay, Sydney, Australia; Macquarie 
      University, Department of Biological Sciences, Sydney, Australia.
FAU - Green, Timothy
AU  - Green T
AD  - Sydney Institute of Marine Science, Chowder Bay, Sydney, Australia; Macquarie 
      University, Department of Biological Sciences, Sydney, Australia. Electronic 
      address: timothy.green@viu.ca.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180929
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Antiviral Agents)
RN  - 0 (Viral Vaccines)
RN  - O84C90HH2L (Poly I-C)
RN  - Ostreid herpesvirus 1
SB  - IM
MH  - Animals
MH  - Antiviral Agents
MH  - Crassostrea/*immunology
MH  - DNA Virus Infections/*immunology
MH  - DNA Viruses/*physiology
MH  - Female
MH  - Fish Diseases/*immunology
MH  - Immunity, Innate
MH  - Immunity, Maternally-Acquired
MH  - Larva
MH  - Male
MH  - *Maternal Exposure
MH  - Ovum/immunology/virology
MH  - Paternal Exposure
MH  - Poly I-C/*immunology
MH  - Viral Vaccines/*immunology
OTO - NOTNLM
OT  - Crassostrea gigas
OT  - OsHV-1
OT  - RNA-seq
OT  - Trained immunity
OT  - Transgenerational immune priming
EDAT- 2018/10/03 06:00
MHDA- 2019/04/09 06:00
CRDT- 2018/10/03 06:00
PHST- 2018/07/05 00:00 [received]
PHST- 2018/09/03 00:00 [revised]
PHST- 2018/09/26 00:00 [accepted]
PHST- 2018/10/03 06:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
PHST- 2018/10/03 06:00 [entrez]
AID - S0145-305X(18)30349-5 [pii]
AID - 10.1016/j.dci.2018.09.022 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2019 Feb;91:17-25. doi: 10.1016/j.dci.2018.09.022. Epub 2018 
      Sep 29.