PMID- 30279452
OWN - NLM
STAT- MEDLINE
DCOM- 20191209
LR  - 20240402
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Oct 2
TI  - Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes.
PG  - 14686
LID - 10.1038/s41598-018-32983-1 [doi]
LID - 14686
AB  - In this study we conducted a cross sectional study to comprehensively evaluated 
      the risk factors of chronic kidney disease (CKD) in a large sample of Chinese 
      adults under primary care for type 2 diabetes mellitus (T2DM). We investigated 
      the risk factors associated with the prevalence of CKD in adults with T2DM, who 
      were enrolled in the Risk Factor Assessment and Management Programme for Patients 
      with Diabetes Mellitus (RAMP-DM) of Hong Kong from July 2014 to June 2017. We 
      collected the individual data of 31,574 subjects, with mean age of 63.0 (+/-10.8) 
      years and mean DM duration of 7.4 (+/-6.4) years. Of them 9,386 (29.7%) had CKD and 
      7,452 (23.6%) had micro- or macro-albuminuria. After adjustment for multiple 
      demographic and lifestyle confounders, we identified several modifiable risk 
      factors associated with higher rate of CKD: obesity (OR = 1.54), current smoking 
      (OR = 1.33), higher systolic blood pressure (OR = 1.01), dyslipidemia (OR = 1.32 
      and 0.61 for triglycerides (TG) and high-density lipoprotein cholesterol 
      (HDL-C)), hyperglycemia (OR = 1.11 for HbA(1c)), diabetic retinopathy (OR = 1.36 
      and 2.60 for non-sight and sight threatening retinopathy), and stroke 
      (OR = 1.43). The risk factors of lower dialytic blood pressure and coronary heart 
      disease were identified only in men, whereas peripheral arterial disease only in 
      women. In conclusion, several modifiable and gender specific risk factors were 
      significantly associated with higher prevalence of CKD in Chinese adults with 
      T2DM. The high-risk populations identified in this study shall receive regular 
      screening for renal functions to achieve better patient management in primary 
      care settings.
FAU - Yang, Lin
AU  - Yang L
AUID- ORCID: 0000-0002-5964-3233
AD  - School of Nursing, The Hong Kong Polytechnic University, Hong Kong Special 
      Administrative Region, China.
FAU - Chu, Tsun Kit
AU  - Chu TK
AD  - Department of Family Medicine & Primary Healthcare, New Territory West Cluster, 
      Hospital Authority, Hong Kong Special Administrative Region, China.
FAU - Lian, Jinxiao
AU  - Lian J
AD  - School of Optometry, The Hong Kong Polytechnic University, Hong Kong Special 
      Administrative Region, China.
FAU - Lo, Cheuk Wai
AU  - Lo CW
AD  - Department of Family Medicine & Primary Healthcare, New Territory West Cluster, 
      Hospital Authority, Hong Kong Special Administrative Region, China.
FAU - Lau, Pak Ki
AU  - Lau PK
AD  - School of Nursing, The Hong Kong Polytechnic University, Hong Kong Special 
      Administrative Region, China.
FAU - Nan, Hairong
AU  - Nan H
AD  - Faculty of Health and Social Science, The Hong Kong Polytechnic University, Hong 
      Kong Special Administrative Region, China.
FAU - Liang, Jun
AU  - Liang J
AD  - Department of Family Medicine & Primary Healthcare, New Territory West Cluster, 
      Hospital Authority, Hong Kong Special Administrative Region, China. 
      liangj@ha.org.hk.
LA  - eng
PT  - Journal Article
DEP - 20181002
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/*epidemiology
MH  - Female
MH  - Hong Kong
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
PMC - PMC6168551
COIS- The authors declare no competing interests.
EDAT- 2018/10/04 06:00
MHDA- 2019/12/18 06:00
PMCR- 2018/10/02
CRDT- 2018/10/04 06:00
PHST- 2018/04/25 00:00 [received]
PHST- 2018/09/14 00:00 [accepted]
PHST- 2018/10/04 06:00 [entrez]
PHST- 2018/10/04 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/10/02 00:00 [pmc-release]
AID - 10.1038/s41598-018-32983-1 [pii]
AID - 32983 [pii]
AID - 10.1038/s41598-018-32983-1 [doi]
PST - epublish
SO  - Sci Rep. 2018 Oct 2;8(1):14686. doi: 10.1038/s41598-018-32983-1.