PMID- 30280055 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 10 IP - 7 DP - 2018 Jul 27 TI - Persistent Psychosis due to Single Dose of Ecstasy. PG - e3058 LID - 10.7759/cureus.3058 [doi] LID - e3058 AB - Ecstasy, a popular drug among the younger generation, the primary psychoactive component of which is 3,4-Methylenedioxymethamphetamine (MDMA), is rarely known to have acute psychiatric effects and when it does, it is usually short term. We describe a patient who presented to the emergency room in a psychotic state after using ecstasy recreationally. Given his aggressive behavior in the community and risk for self-harm, he was emergently hospitalized to ensure safety. He developed persistent psychotic symptoms (delusions) after one dose of recreational MDMA and the team had the opportunity to observe, monitor, and treat his psychosis. This case along with few other documented cases highlights the gaps in research about the chronic, persistent effects and long-term consequences of MDMA. It also suggests that neuropsychiatric symptoms may not be readily reversible after cessation of use. There is an emphasis on the need for physicians to inquire about MDMA use and include it in toxicology screenings and as a potential differential diagnosis. FAU - Virani, Sanya AU - Virani S AD - Psychiatry, Maimonides Medical Center, Brooklyn, USA. FAU - Daya, Gulzar N AU - Daya GN AD - Biology, Loyola University, Chicago, USA. FAU - Brainch, Navjot AU - Brainch N AD - Psychiatry, Maimonides Medical Center, Brooklyn, USA. FAU - Kotapati, Vijaya Padma AU - Kotapati VP AD - Psychiatry, Manhattan Psychiatric Center, New York, USA. FAU - Zaveri, Deval AU - Zaveri D AD - Psychiatry, Maimonides Medical Center, New York, USA. FAU - Ahmed, Saeed AU - Ahmed S AD - Behavioral Health Sciences, Nassau University Medical Center, East Meadow, USA. LA - eng PT - Case Reports DEP - 20180727 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC6166901 OTO - NOTNLM OT - ecstasy OT - mdma OT - psychosis COIS- The authors have declared that no competing interests exist. EDAT- 2018/10/04 06:00 MHDA- 2018/10/04 06:01 PMCR- 2018/07/27 CRDT- 2018/10/04 06:00 PHST- 2018/10/04 06:00 [entrez] PHST- 2018/10/04 06:00 [pubmed] PHST- 2018/10/04 06:01 [medline] PHST- 2018/07/27 00:00 [pmc-release] AID - 10.7759/cureus.3058 [doi] PST - epublish SO - Cureus. 2018 Jul 27;10(7):e3058. doi: 10.7759/cureus.3058.