PMID- 30280270
OWN - NLM
STAT- MEDLINE
DCOM- 20190912
LR  - 20190912
IS  - 1539-0829 (Electronic)
IS  - 1534-4827 (Linking)
VI  - 18
IP  - 11
DP  - 2018 Oct 2
TI  - Epigenetics Variation and Pathogenesis in Diabetes.
PG  - 121
LID - 10.1007/s11892-018-1091-4 [doi]
AB  - PURPOSE OF REVIEW: Great strides have recently been made in elucidating the role 
      of genetic sequence variation in diabetes pathogenesis. Increasingly, studies are 
      focusing on other factors that may contribute to the pathogenesis of diabetes, 
      such as epigenetics, a term "traditionally" encompassing changes to the DNA that 
      do not alter sequence and are heritable (primary methylation and histone 
      modification) but often expanded to include microRNAs. This review summarizes 
      latest findings on the role of epigenetics in diabetes pathogenesis. RECENT 
      FINDINGS: Recent studies illustrate roles for methylation changes, histone 
      modification, imprinting, and microRNAs across several diabetes types and 
      complications. Notably, methylation changes in the human leukocyte antigen (HLA) 
      region have been found to precede the development of type 1 diabetes. In type 2 
      diabetes, lifestyle factors appear to interact with epigenetic mechanisms in 
      pathogenesis. Emerging technologies have allowed increasingly comprehensive 
      descriptive analysis of the role of epigenetic mechanisms in diabetes 
      pathogenesis which have yielded meaningful insights into effects on expression of 
      relevant genes. These findings have the potential to inform future development of 
      predictive testing to enable primary prevention and further work to uncover the 
      complex pathogenesis of diabetes.
FAU - Zhang, Haichen
AU  - Zhang H
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Nutrition Program 
      for Personalized and Genomic Medicine, University of Maryland School of Medicine, 
      670 West Baltimore Street, Room 4040, Baltimore, MD, 21201, USA.
FAU - Pollin, Toni I
AU  - Pollin TI
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Nutrition Program 
      for Personalized and Genomic Medicine, Department of Epidemiology and Public 
      Health, University of Maryland School of Medicine, 670 West Baltimore Street, 
      Room 4040, Baltimore, MD, 21201, USA. tpollin@som.umaryland.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181002
PL  - United States
TA  - Curr Diab Rep
JT  - Current diabetes reports
JID - 101093791
RN  - 0 (Histones)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - DNA Methylation/genetics
MH  - Diabetes Mellitus/*genetics
MH  - *Epigenesis, Genetic
MH  - Genomic Imprinting
MH  - Histones/metabolism
MH  - Humans
MH  - MicroRNAs/genetics/metabolism
OTO - NOTNLM
OT  - DNA methylation
OT  - Diabetes
OT  - Epigenetics
OT  - Histone modification
OT  - microRNAs
EDAT- 2018/10/04 06:00
MHDA- 2019/09/13 06:00
CRDT- 2018/10/04 06:00
PHST- 2018/10/04 06:00 [entrez]
PHST- 2018/10/04 06:00 [pubmed]
PHST- 2019/09/13 06:00 [medline]
AID - 10.1007/s11892-018-1091-4 [pii]
AID - 10.1007/s11892-018-1091-4 [doi]
PST - epublish
SO  - Curr Diab Rep. 2018 Oct 2;18(11):121. doi: 10.1007/s11892-018-1091-4.