PMID- 30280285
OWN - NLM
STAT- MEDLINE
DCOM- 20190606
LR  - 20211204
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 34
IP  - 1
DP  - 2019 Feb
TI  - Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress.
PG  - 93-101
LID - 10.1007/s11011-018-0328-x [doi]
AB  - Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally occurring polyphenolic 
      compound. Previous study has shown that gallic acid possessed significant 
      antidepressant-like activity in mice, which was partly mediated by increasing 
      serotonin and catecholamine levels. The main aim of the present study is to 
      investigate the possible effects of gallic acid on brain-derived neurotrophic 
      factor (BDNF) signaling activation. Mice were exposed to chronic mild stress 
      (CMS) and orally administrated with gallic acid for four weeks. The behavioral 
      results showed that gallic acid not only reversed the decreased sucrose 
      preference, but also attenuated the increased immobility time. In addition, 
      gallic acid promoted both the BDNF and p-TrkB levels in the hippocampus induced 
      by CMS. Moreover, the results also demonstrated that the inactivated Akt-mTOR 
      signaling pathway, as well as its downstream effectors induced by CMS was 
      activated again by gallic acid. Last, immunofluorescence detection indicated that 
      gallic acid reversed the newborn neurons inhibition in the dentate gyrus by CMS. 
      In conclusion, these results show that the activation of the hippocampal 
      BDNF-Akt-mTOR signaling is involved in the antidepressant-like effects of gallic 
      acid.
FAU - Zhu, Ji-Xiao
AU  - Zhu JX
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, 
      Jiangxi province, People's Republic of China.
FAU - Shan, Jia-Ling
AU  - Shan JL
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, 
      Jiangxi province, People's Republic of China.
FAU - Hu, Wei-Qiong
AU  - Hu WQ
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, 
      Jiangxi province, People's Republic of China.
FAU - Zeng, Jin-Xiang
AU  - Zeng JX
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, 
      Jiangxi province, People's Republic of China.
FAU - Shu, Ji-Cheng
AU  - Shu JC
AD  - Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic 
      Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, 
      Jiangxi province, People's Republic of China. jxutcm_zjx@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181003
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 632XD903SP (Gallic Acid)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Gallic Acid/*pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Mice
MH  - Neurons/drug effects/metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Signal Transduction/*drug effects
MH  - Stress, Psychological/*metabolism
MH  - TOR Serine-Threonine Kinases
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Chronic mild stress (CMS)
OT  - Gallic acid
EDAT- 2018/10/04 06:00
MHDA- 2019/06/07 06:00
CRDT- 2018/10/04 06:00
PHST- 2018/08/09 00:00 [received]
PHST- 2018/09/27 00:00 [accepted]
PHST- 2018/10/04 06:00 [pubmed]
PHST- 2019/06/07 06:00 [medline]
PHST- 2018/10/04 06:00 [entrez]
AID - 10.1007/s11011-018-0328-x [pii]
AID - 10.1007/s11011-018-0328-x [doi]
PST - ppublish
SO  - Metab Brain Dis. 2019 Feb;34(1):93-101. doi: 10.1007/s11011-018-0328-x. Epub 2018 
      Oct 3.