PMID- 30280803
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20191114
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 22
IP  - 18
DP  - 2018 Sep
TI  - Protective effect of simvastatin on arterial plaque instability induced by 
      p-cresyl sulfate.
PG  - 6149-6155
LID - 15955 [pii]
LID - 10.26355/eurrev_201809_15955 [doi]
AB  - OBJECTIVE: To study the protective effect of simvastatin on arterial plaque 
      instability induced by p-cresyl sulfate (PCS). MATERIALS AND METHODS: 
      Apolipoprotein E (ApoE)-/- mice were selected as objects of this study. All mice 
      were randomly divided into three groups: 1) the control group, 2) the PCS group 
      and 3) the PCS + simvastatin group. After successful modeling, the levels of 
      plasma cholesterol, triglyceride, low-density lipoprotein, high-density 
      lipoprotein, interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis 
      factor-beta (TNF-beta) were detected. The gross specimen of coronary artery was 
      stained. Meanwhile, oil red O staining and Sirius red staining were performed for 
      coronary arterial sections to observe the lipid and collagen components. The 
      expression levels of smooth muscle cells and macrophages were observed by 
      immunohistochemistry. In addition, the expression levels of matrix 
      metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and 
      monocyte chemoattractant protein-1 (MCP-1) in tissues were detected by Western 
      blotting. RESULTS: Simvastatin could improve atherosclerotic plaque growth and 
      atherosclerotic plaque instability induced by PCS. Moreover, simvastatin could 
      also improve the changes of MMPs and TIMPs caused by PCS as well as the 
      inflammatory status in mice. CONCLUSIONS: Simvastatin can improve the 
      inflammatory status in mice, eventually improving the arterial plaque instability 
      caused by PCS.
FAU - Li, H-Y
AU  - Li HY
AD  - EICU, Yantai Yuhuangding Hospital, Yantai, China. yfvb93@163.com.
FAU - Liu, F
AU  - Liu F
FAU - Gao, C
AU  - Gao C
FAU - Wang, H-R
AU  - Wang HR
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Cresols)
RN  - 0 (Lipids)
RN  - 0 (Protective Agents)
RN  - 0 (Sulfuric Acid Esters)
RN  - 56M34ZQY1S (4-cresol sulfate)
RN  - AGG2FN16EV (Simvastatin)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Cresols/*toxicity
MH  - Lipids/blood
MH  - Male
MH  - Matrix Metalloproteinases/metabolism
MH  - Mice
MH  - Plaque, Atherosclerotic/*drug therapy/metabolism/pathology
MH  - Protective Agents/therapeutic use
MH  - Simvastatin/pharmacology/*therapeutic use
MH  - Sulfuric Acid Esters/*toxicity
EDAT- 2018/10/04 06:00
MHDA- 2019/11/15 06:00
CRDT- 2018/10/04 06:00
PHST- 2018/10/04 06:00 [entrez]
PHST- 2018/10/04 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
AID - 15955 [pii]
AID - 10.26355/eurrev_201809_15955 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2018 Sep;22(18):6149-6155. doi: 
      10.26355/eurrev_201809_15955.