PMID- 30281927
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20190805
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 8
IP  - 11
DP  - 2018 Nov
TI  - B cell lymphoma-2-like protein-12 association with T-helper 2 inflammation in 
      chronic rhinosinusitis with allergy.
PG  - 1300-1307
LID - 10.1002/alr.22223 [doi]
AB  - BACKGROUND: T-helper 2 (Th2) polarization plays a critical role in the 
      pathogenesis of chronic rhinosinusitis (CRS) with accompanying nasal allergy. 
      Recent studies indicate that B cell lymphoma-2-like protein-12 (Bcl2L12) is 
      associated with immune dysregulation. The purpose of this study was to elucidate 
      the role of Bcl2L12 in the pathogenesis of Th2 polarization of CRS patients. 
      METHODS: CRS patients with nasal allergy (CRSa) and without nasal allergy (CRSna) 
      were recruited into this study. CD4(+) T cells were isolated from the blood 
      samples of human subjects. A variety of immunologic molecular strategies were 
      used to assess Th2 polarization and Bcl2L12 expression. RESULTS: Twenty CRSa 
      patients, 20 CRSna patients, and 20 healthy subjects were recruited into this 
      study. High levels of immunoglobulin E (IgE), interleukin 4 (IL-4), IL-5, IL-13, 
      and Bcl2L12 were detected in nasal extracts of CRSa patients, but not in CRSna 
      patients. The levels of Bcl2L12 were positively correlated with Th2 cytokines. 
      CD4(+) T cells from CRSa patients were prone to differentiate into Th2 cells, in 
      which Bcl2L12 was required. CONCLUSION: Bcl2L12 is positively correlated with Th2 
      cytokine levels in the nasal mucosa of CRSa patients. Bcl2L12 contributes to the 
      Th2 polarization, which may be a novel therapeutic target in the treatment of 
      CRSa.
CI  - (c) 2018 ARS-AAOA, LLC.
FAU - An, Yun-Fang
AU  - An YF
AD  - Department of Otolaryngology, Head & Neck Surgery, the Second Hospital, Shanxi 
      Medical University, Taiyuan, China.
FAU - Wu, Yong-Jin
AU  - Wu YJ
AD  - Ear-Nose-Throat (ENT) Institute and Research Center of Allergy & Immunology, 
      Shenzhen University School of Medicine, Shenzhen, China.
AD  - Longgang Ear-Nose-Throat (ENT) Hospital, Shenzhen, China.
FAU - Zeng, Xian-Hai
AU  - Zeng XH
AD  - Ear-Nose-Throat (ENT) Institute and Research Center of Allergy & Immunology, 
      Shenzhen University School of Medicine, Shenzhen, China.
AD  - Longgang Ear-Nose-Throat (ENT) Hospital, Shenzhen, China.
FAU - Song, Li-Juan
AU  - Song LJ
AD  - Department of Otolaryngology, Head & Neck Surgery, the First Hospital, Guangzhou 
      Medical University, Guangzhou, China.
FAU - Ma, Fei
AU  - Ma F
AD  - Department of Otolaryngology, Head & Neck Surgery, the First Hospital, Guangzhou 
      Medical University, Guangzhou, China.
FAU - Liao, Wen-Jing
AU  - Liao WJ
AD  - Department of Otolaryngology, Head & Neck Surgery, the First Hospital, Guangzhou 
      Medical University, Guangzhou, China.
FAU - Liu, Zhi-Qiang
AU  - Liu ZQ
AUID- ORCID: 0000-0001-6627-5726
AD  - Ear-Nose-Throat (ENT) Institute and Research Center of Allergy & Immunology, 
      Shenzhen University School of Medicine, Shenzhen, China.
AD  - Longgang Ear-Nose-Throat (ENT) Hospital, Shenzhen, China.
FAU - Yang, Gui
AU  - Yang G
AD  - Ear-Nose-Throat (ENT) Institute and Research Center of Allergy & Immunology, 
      Shenzhen University School of Medicine, Shenzhen, China.
AD  - Longgang Ear-Nose-Throat (ENT) Hospital, Shenzhen, China.
FAU - Zhang, Xiao-Wen
AU  - Zhang XW
AD  - Department of Otolaryngology, Head & Neck Surgery, the First Hospital, Guangzhou 
      Medical University, Guangzhou, China.
FAU - Liu, Zhi-Gang
AU  - Liu ZG
AD  - Ear-Nose-Throat (ENT) Institute and Research Center of Allergy & Immunology, 
      Shenzhen University School of Medicine, Shenzhen, China.
FAU - Zhao, Chang-Qing
AU  - Zhao CQ
AD  - Department of Otolaryngology, Head & Neck Surgery, the Second Hospital, Shanxi 
      Medical University, Taiyuan, China.
FAU - Yang, Ping-Chang
AU  - Yang PC
AUID- ORCID: 0000-0002-3650-0416
AD  - Ear-Nose-Throat (ENT) Institute and Research Center of Allergy & Immunology, 
      Shenzhen University School of Medicine, Shenzhen, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181003
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (BCL2L12 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (Muscle Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
MH  - Adult
MH  - Chronic Disease
MH  - Cytokines/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Male
MH  - Muscle Proteins/*immunology
MH  - Nasal Mucosa/immunology
MH  - Proto-Oncogene Proteins c-bcl-2/*immunology
MH  - Rhinitis/*immunology
MH  - Sinusitis/*immunology
MH  - Th2 Cells/*immunology
OTO - NOTNLM
OT  - Bcl2L12
OT  - immunity
OT  - inflammation
OT  - lymphocyte
OT  - rhinosinusitis
EDAT- 2018/10/04 06:00
MHDA- 2019/08/06 06:00
CRDT- 2018/10/04 06:00
PHST- 2018/06/03 00:00 [received]
PHST- 2018/09/10 00:00 [revised]
PHST- 2018/09/12 00:00 [accepted]
PHST- 2018/10/04 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
PHST- 2018/10/04 06:00 [entrez]
AID - 10.1002/alr.22223 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2018 Nov;8(11):1300-1307. doi: 10.1002/alr.22223. Epub 
      2018 Oct 3.