PMID- 302842
OWN - NLM
STAT- MEDLINE
DCOM- 19771130
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 60
IP  - 4
DP  - 1977 Oct
TI  - Relative refractory state for late cutaneous allergic responses.
PG  - 242-6
AB  - The late cutaneous allergic response (LCAR) is a usual sequel to the 
      wheal-and-flare (early) response in sufficiently intense cutaneous allergic 
      reactions. Allergic reactions with early and late components were produced in the 
      skin of the forearm by the intracutaneous injection of anti-IgE or allergen. One 
      week later, these sites, which were normal in gross appearance, and separate 
      control sites on the opposite forearm, were injected. At the sites of repeat 
      reactions, the wheal diameter of the early response was the same but the LCAR was 
      considerably smaller than at simultaneously injected control sites. This local 
      relative refractory state for LCAR is immunologically nonspecific in the sense 
      that it was manifest even when the antigen injected the second time had no 
      evident immunologic relationship with the antigen injected initially. The 
      refractory state for LCAR was present at 2 wk after the initial reaction, but it 
      was no longer demonstrable after 3 wk. This local relative refractory state for 
      LCAR may represent an inhibitory control mechanism for allergic reactions in man.
FAU - Shaikh, W
AU  - Shaikh W
FAU - Umemoto, L
AU  - Umemoto L
FAU - Poothullil, J
AU  - Poothullil J
FAU - Hargreave, F E
AU  - Hargreave FE
FAU - Dolovich, J
AU  - Dolovich J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Allergens)
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/administration & dosage
MH  - Antibodies, Anti-Idiotypic/administration & dosage
MH  - Dermatitis, Contact/*immunology
MH  - Erythema/immunology
MH  - Humans
MH  - Immunoglobulin E
MH  - Intradermal Tests
MH  - Reaction Time
MH  - Respiratory Hypersensitivity/immunology
EDAT- 1977/10/01 00:00
MHDA- 1977/10/01 00:01
CRDT- 1977/10/01 00:00
PHST- 1977/10/01 00:00 [pubmed]
PHST- 1977/10/01 00:01 [medline]
PHST- 1977/10/01 00:00 [entrez]
AID - 0091-6749(77)90138-5 [pii]
AID - 10.1016/0091-6749(77)90138-5 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 1977 Oct;60(4):242-6. doi: 10.1016/0091-6749(77)90138-5.