PMID- 30285067
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 151
IP  - 4
DP  - 2019 Mar 1
TI  - HLA-Mediated Platelet Refractoriness.
PG  - 353-363
LID - 10.1093/ajcp/aqy121 [doi]
AB  - OBJECTIVES: To provide an overview of the complexities associated with the human 
      leukocyte antigen (HLA)-mediated platelet refractoriness. HLA antibody detection 
      technologies and limitations associated with methodologies are discussed. 
      METHODS: A case scenario and review of relevant literature describing platelet 
      refractoriness are presented, followed by a discussion of HLA antibody testing. 
      RESULTS: Following diagnosis of HLA-mediated refractoriness, a decision is made 
      regarding the approach to obtain the appropriate platelets. The panel reactive 
      antibodies (PRA) % of the patient, HLA typing, and limitations of the HLA testing 
      should be taken into account when deciding which type of product would be the 
      best option for a given patient. CONCLUSIONS: Following confirmation and review 
      of HLA antibody testing, platelets are ordered based upon the PRA% and approach 
      employed, HLA-matched platelets, antigen restricted platelets, or cross-matched 
      platelets. The platelets are transfused and a posttransfusion increment count is 
      monitored to determine transfusion success.
CI  - (c) American Society for Clinical Pathology, 2018. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Schmidt, Amy E
AU  - Schmidt AE
AD  - Department of Pathology and Laboratory Medicine, University of Rochester Medical 
      Center, Rochester, NY.
FAU - Refaai, Majed A
AU  - Refaai MA
AD  - Department of Pathology and Laboratory Medicine, University of Rochester Medical 
      Center, Rochester, NY.
FAU - Coppage, Myra
AU  - Coppage M
AD  - Department of Pathology and Laboratory Medicine, University of Rochester Medical 
      Center, Rochester, NY.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aged, 80 and over
MH  - Antibody Specificity/immunology
MH  - Blood Grouping and Crossmatching
MH  - Blood Platelets/*immunology
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Platelet Transfusion
MH  - Thrombocytopenia/*immunology/therapy
MH  - Transfusion Reaction/*immunology
OTO - NOTNLM
OT  - Complement-dependent cytotoxicity test
OT  - HLA
OT  - HLA antibody
OT  - Platelet refractory
EDAT- 2018/10/05 06:00
MHDA- 2019/12/31 06:00
CRDT- 2018/10/05 06:00
PHST- 2018/10/05 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2018/10/05 06:00 [entrez]
AID - 5114639 [pii]
AID - 10.1093/ajcp/aqy121 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2019 Mar 1;151(4):353-363. doi: 10.1093/ajcp/aqy121.