PMID- 30285090
OWN - NLM
STAT- MEDLINE
DCOM- 20191226
LR  - 20240410
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 74
IP  - 4
DP  - 2019 Mar 14
TI  - Meaningful Change Estimates for the Late-Life Function and Disability Instrument 
      in Older Adults.
PG  - 556-559
LID - 10.1093/gerona/gly230 [doi]
AB  - BACKGROUND: The Late-Life Function and Disability Instrument (LLFDI) is a 
      well-validated and frequently used patient-reported outcome for older adults. The 
      aim of this study was to estimate the minimal clinically important difference 
      (MCID) of the LLFDI-Function Component (LLFDI-FC) and its subscales among 
      community-dwelling older adults with mobility limitations. METHODS: We performed 
      a secondary analysis of the Boston Rehabilitative Impairment Study of the 
      Elderly, a longitudinal cohort study of older adults with mobility limitations 
      residing in the community. The MCID for each LLFDI-FC scale over 1 year of 
      follow-up was estimated using both anchor- and distribution-based methods, 
      including mean change scores on a patient-reported global rating of change in 
      function scale, the standard error of measurement (SEM), and the minimal 
      detectable change with 90% confidence (MDC90). RESULTS: Data from 320 older 
      adults were used in the analysis (mean age 76 years, 69% female, mean of four 
      chronic conditions). Meaningful change estimates for "small change" based on the 
      global rating of change and SEM were 2, 3, 4, and 4 points for the LLFDI-FC 
      overall function scale and basic lower-extremity, advanced lower-extremity, and 
      upper-extremity subscales, respectively. Estimates for "substantial change" based 
      on the global rating of change and minimal detectable change with 90% confidence 
      were 5, 6, 9, and 10 points for the overall function scale and basic 
      lower-extremity, advanced lower-extremity, and upper-extremity subscales, 
      respectively. CONCLUSION: This study provides the first MCID estimates for the 
      LLFDI-FC, a widely used patient-reported measure of function. These values can be 
      used to interpret the outcomes of longitudinal investigations of functional 
      status in similar populations of community-dwelling older adults.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Beauchamp, Marla K
AU  - Beauchamp MK
AD  - School of Rehabilitation Science, Ontario, Canada.
AD  - Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
AD  - Respiratory Research, West Park Healthcare Centre, Toronto, Ontario, Canada.
FAU - Ward, Rachel E
AU  - Ward RE
AD  - New England Geriatric Research Education and Clinical Center, Veterans 
      Administration Boston Health System, Massachusetts.
FAU - Jette, Alan M
AU  - Jette AM
AD  - Health and Disability Research Institute, Boston University School of Health, 
      Massachusetts.
FAU - Bean, Jonathan F
AU  - Bean JF
AD  - New England Geriatric Research Education and Clinical Center, Veterans 
      Administration Boston Health System, Massachusetts.
AD  - Department of Physical Medicine and Rehabilitation, Harvard Medical School, 
      Boston, Massachusetts.
AD  - Spaulding Rehabilitation Hospital, Boston, Massachusetts.
LA  - eng
GR  - K24 HD070966/HD/NICHD NIH HHS/United States
GR  - R01 AG032052/AG/NIA NIH HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - *Disability Evaluation
MH  - Female
MH  - *Geriatric Assessment
MH  - Humans
MH  - Independent Living
MH  - Longitudinal Studies
MH  - Male
MH  - *Mobility Limitation
MH  - Patient Reported Outcome Measures
PMC - PMC6417450
OTO - NOTNLM
OT  - Clinically important difference
OT  - Measurement
OT  - Minimal important change
OT  - Responsiveness
OT  - Self-reported function
EDAT- 2018/10/05 06:00
MHDA- 2019/12/27 06:00
PMCR- 2019/10/04
CRDT- 2018/10/05 06:00
PHST- 2018/04/06 00:00 [received]
PHST- 2018/10/05 06:00 [pubmed]
PHST- 2019/12/27 06:00 [medline]
PHST- 2018/10/05 06:00 [entrez]
PHST- 2019/10/04 00:00 [pmc-release]
AID - 5114863 [pii]
AID - gly230 [pii]
AID - 10.1093/gerona/gly230 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):556-559. doi: 
      10.1093/gerona/gly230.