PMID- 30286482
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 50
IP  - 11
DP  - 2018 Nov
TI  - Ghrelin Levels in Basal Conditions and During Glucose Tolerance Test in 
      Prediabetic and Diabetic Patients.
PG  - 822-826
LID - 10.1055/a-0746-4014 [doi]
AB  - Ghrelin is associated with glucose homeostasis but its' possible relevance with 
      glucose levels in physiological and pathological conditions has so far been 
      poorly investigated. The aim of the present study was to evaluate circulating 
      ghrelin levels in prediabetic and diabetic patients in basal conditions and in 
      response to oral glucose tolerance test (OGTT). A total of 90 male adults aged 40 
      - 73 years old were enrolled in our study. Fasting and postprandial plasma 
      ghrelin, insulin and glucose levels were measured at 0, 60, 120 and 180 min 
      following an OGTT in 40 patients with type 2 diabetes mellitus (T2DM), 20 with 
      impaired glucose tolerance (IGT) and 30 controls. Incremental and total area 
      under response curve were determined and calculated for glucose, insulin and 
      ghrelin. Fasting plasma ghrelin concentrations were significantly lower in the 
      T2DM group than IGT and control group patients (p<0.01) but not between healthy 
      subjects and IGT group (p=0.746). In the diabetics' group ghrelin levels showed a 
      statistically significant negative correlation with insulin and a positive 
      correlation with HbA1c and glucose. At all time points after the OGTT ghrelin 
      concentrations were significantly lower in the T2DM group compared to IGT group 
      and controls. Plasma ghrelin concentrations are lower in male diabetic patients 
      at the fasting state and remain lower at all time points after an OGTT while 
      minor differences were found between normal and IGT subjects. Ghrelin might play 
      a role in insulin and glucose metabolism in diabetic patients but not in patients 
      with IGT.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Bounias, Ioannis
AU  - Bounias I
AD  - Medical School, Division of Endocrinology, Democritus University of Thrace, 
      Alexandroupolis, Greece.
FAU - Pouliliou, Stamatia
AU  - Pouliliou S
AD  - Medical School, Department of Radiotherapy/Oncology, Democritus University of 
      Thrace, Alexandroupolis, Greece.
FAU - Tripsianis, Gregory
AU  - Tripsianis G
AD  - Department of Medical Statistics, Democritus Univeristy of Thrace, 
      Alexandroupolis, Greece.
FAU - Antonoglou, Cristos
AU  - Antonoglou C
AD  - Medical School, Second Department of Internal Medicine, Democritus University of 
      Thrace, Alexandroupolis, Greece.
FAU - Papazoglou, Anna
AU  - Papazoglou A
AD  - Medical School, Second Department of Internal Medicine, Democritus University of 
      Thrace, Alexandroupolis, Greece.
FAU - Maltezos, Efstratios
AU  - Maltezos E
AD  - Medical School, Second Department of Internal Medicine, Democritus University of 
      Thrace, Alexandroupolis, Greece.
FAU - Papazoglou, Dimitrios
AU  - Papazoglou D
AD  - Medical School, Second Department of Internal Medicine, Democritus University of 
      Thrace, Alexandroupolis, Greece.
LA  - eng
PT  - Journal Article
DEP - 20181004
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Blood Glucose)
RN  - 0 (Ghrelin)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fasting/blood
MH  - Female
MH  - Ghrelin/*blood
MH  - Glucose Intolerance/blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*blood
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/10/05 06:00
MHDA- 2019/05/07 06:00
CRDT- 2018/10/05 06:00
PHST- 2018/10/05 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
PHST- 2018/10/05 06:00 [entrez]
AID - 10.1055/a-0746-4014 [doi]
PST - ppublish
SO  - Horm Metab Res. 2018 Nov;50(11):822-826. doi: 10.1055/a-0746-4014. Epub 2018 Oct 
      4.