PMID- 3028904
OWN - NLM
STAT- MEDLINE
DCOM- 19870413
LR  - 20191210
IS  - 0016-6480 (Print)
IS  - 0016-6480 (Linking)
VI  - 65
IP  - 2
DP  - 1987 Feb
TI  - Effects of cortisol and growth hormone on osmoregulation in pre- and desmoltified 
      coho salmon (Oncorhynchus kisutch).
PG  - 189-98
AB  - Salmonid species which undergo smoltification show a concurrent enhancement in 
      saltwater (SW) osmoregulatory ability. This developmental change is marked by an 
      increase in SW tolerance and gill Na+,K+-ATPase activity which appears to result, 
      in part, from an increase in gill chloride cell density. Previous studies have 
      suggested that cortisol and growth hormone (GH) may stimulate SW osmoregulatory 
      mechanisms in salmonids. In this study, these hormones were examined for their 
      ability to induce smoltification-associated osmoregulatory changes in pre- and 
      desmoltified coho salmon (Oncorhynchus kisutch). Cortisol treatment for 12 days 
      increased gill Na+,K+-ATPase activity in presmolts and gill residual 
      (Na+,K+-independent) ATPase activity in both groups. Chloride cell density in 
      presmolt primary and secondary lamellae and in desmolt secondary lamellae was 
      increased as well. The rise in plasma sodium levels in fish transferred to SW was 
      reduced only in desmolts. Treatment with bovine GH for 12-13 days increased gill 
      Na+,K+-ATPase activity in presmolts and in desmolts. However, GH treatment in 
      either group did not increase gill residual ATPase activity or alter plasma 
      sodium levels in SW-transferred animals. Gill chloride cell density in presmolts 
      also was unaffected (desmolts were not examined). Thus, both cortisol and GH are 
      partially able to produce changes similar to those observed during 
      smoltification. The contrasting effects of these hormones on gill chloride cell 
      density and gill residual ATPase activity suggest that cortisol may stimulate 
      chloride cell proliferation and/or differentiation, whereas GH may act 
      specifically to increase gill Na+,K+-ATPase activity.
FAU - Richman, N H 3rd
AU  - Richman NH 3rd
FAU - Zaugg, W S
AU  - Zaugg WS
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (Chlorides)
RN  - 9002-72-6 (Growth Hormone)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Chlorides/metabolism
MH  - Gills/drug effects/metabolism
MH  - Growth Hormone/*pharmacology
MH  - Hydrocortisone/*pharmacology
MH  - Salmon/growth & development/*metabolism
MH  - Seawater
MH  - Sodium/blood
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Water-Electrolyte Balance/*drug effects
EDAT- 1987/02/01 00:00
MHDA- 1987/02/01 00:01
CRDT- 1987/02/01 00:00
PHST- 1987/02/01 00:00 [pubmed]
PHST- 1987/02/01 00:01 [medline]
PHST- 1987/02/01 00:00 [entrez]
AID - 10.1016/0016-6480(87)90165-1 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 1987 Feb;65(2):189-98. doi: 10.1016/0016-6480(87)90165-1.