PMID- 30289047
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240306
IS  - 1744-8417 (Electronic)
IS  - 1744-6651 (Linking)
VI  - 10
IP  - 1
DP  - 2015 Jan
TI  - Molecular genetic advances in pituitary tumor development.
PG  - 35-53
LID - 10.1586/17446651.2015.955795 [doi]
AB  - Pituitary adenomas are a heterogeneous group of tumors that may occur as part of 
      a complex syndrome or as an isolated endocrinopathy and both forms can be 
      familial or non-familial. Studies of syndromic and non-syndromic pituitary 
      adenomas have yielded important insights about the molecular mechanisms 
      underlying tumorigenesis. Thus, syndromic forms, including multiple endocrine 
      neoplasia type 1 (MEN1), MEN4, Carney Complex and McCune Albright syndrome, have 
      been shown to be due to mutations of the tumor-suppressor protein menin, a 
      cyclin-dependent kinase inhibitor (p27(Kip1)), the protein kinase A regulatory 
      subunit 1-alpha, and the G-protein alpha-stimulatory subunit (Gsalpha), respectively. 
      Non-syndromic forms, which include familial isolated pituitary adenoma (FIPA) and 
      sporadic tumors, have been shown to be due to abnormalities of: the aryl 
      hydrocarbon receptor-interacting protein; Gsalpha; signal transducers; cell cycle 
      regulators; transcriptional modulators and miRNAs. The roles of these molecular 
      abnormalities and epigenetic mechanisms in pituitary tumorigenesis, and their 
      therapeutic implications are reviewed.
FAU - Yates, Christopher J
AU  - Yates CJ
AD  - a 1 Academic Endocrine Unit, Radcliffe Department of Clinical Medicine, Oxford 
      Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, 
      Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK.
AD  - b 2 Department of Diabetes and Endocrinology, Melbourne Health, The Royal 
      Melbourne Hospital, Grattan Street, Parkville, Vic 3050, Australia.
FAU - Lines, Kate E
AU  - Lines KE
AD  - a 1 Academic Endocrine Unit, Radcliffe Department of Clinical Medicine, Oxford 
      Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, 
      Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK.
FAU - Thakker, Rajesh V
AU  - Thakker RV
AD  - a 1 Academic Endocrine Unit, Radcliffe Department of Clinical Medicine, Oxford 
      Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, 
      Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK.
LA  - eng
GR  - G1000467/MRC_/Medical Research Council/United Kingdom
GR  - G9825289/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20140902
PL  - England
TA  - Expert Rev Endocrinol Metab
JT  - Expert review of endocrinology & metabolism
JID - 101278293
OTO - NOTNLM
OT  - epigenetics
OT  - genetic syndromes
OT  - miRNA
OT  - molecular genetics
OT  - pituitary adenoma
OT  - therapy
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
CRDT- 2018/10/06 06:00
PHST- 2018/10/06 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
AID - 10.1586/17446651.2015.955795 [doi]
PST - ppublish
SO  - Expert Rev Endocrinol Metab. 2015 Jan;10(1):35-53. doi: 
      10.1586/17446651.2015.955795. Epub 2014 Sep 2.