PMID- 30289065 OWN - NLM STAT- MEDLINE DCOM- 20200214 LR - 20200214 IS - 1875-533X (Electronic) IS - 0929-8673 (Linking) VI - 26 IP - 38 DP - 2019 TI - Graphene and Graphene Oxide Applications for SERS Sensing and Imaging. PG - 6878-6895 LID - 10.2174/0929867325666181004152247 [doi] AB - Surface Enhanced Raman Spectroscopy (SERS) has a long history as an ultrasensitive platform for the detection of biological species from small aromatic molecules to complex biological systems as circulating tumor cells. Thanks to unique properties of graphene, the range of SERS applications has largely expanded. Graphene is efficient fluorescence quencher improving quality of Raman spectra. It contributes also to the SERS enhancement factor through the chemical mechanism. In turn, the chemical flexibility of Reduced Graphene Oxide (RGO) enables tunable adsorption of molecules or cells on SERS active surfaces. Graphene oxide composites with SERS active nanoparticles have been also applied for Raman imaging of cells. This review presents a survey of SERS assays employing graphene or RGO emphasizing the improvement of SERS enhancement brought by graphene or RGO. The structure and physical properties of graphene and RGO will be discussed too. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Jablonska, Anna AU - Jablonska A AD - Chemical and Biological Research Centre, University of Warsaw, Zwirki i Wigury str. 101, Warsaw, PL-02- 089, Poland. FAU - Jaworska, Aleksandra AU - Jaworska A AD - Faculty of Chemistry, University of Warsaw, Pasteur str. 1, Warsaw, PL-02-093, Poland. FAU - Kasztelan, Mateusz AU - Kasztelan M AD - Faculty of Chemistry, University of Warsaw, Pasteur str. 1, Warsaw, PL-02-093, Poland. FAU - Berbec, Sylwia AU - Berbec S AD - Faculty of Chemistry, University of Warsaw, Pasteur str. 1, Warsaw, PL-02-093, Poland. FAU - Palys, Barbara AU - Palys B AD - Chemical and Biological Research Centre, University of Warsaw, Zwirki i Wigury str. 101, Warsaw, PL-02- 089, Poland. LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - Curr Med Chem JT - Current medicinal chemistry JID - 9440157 RN - 0 (graphene oxide) RN - 7782-42-5 (Graphite) SB - IM MH - Biosensing Techniques/methods MH - Diagnosis MH - Graphite/*chemistry MH - Humans MH - Oxidation-Reduction MH - Spectrum Analysis, Raman/*methods MH - Theranostic Nanomedicine OTO - NOTNLM OT - SERS platform OT - biosensors OT - cancer cells OT - diagnosis OT - graphene OT - reduced graphene oxide OT - theranostics. EDAT- 2018/10/06 06:00 MHDA- 2020/02/15 06:00 CRDT- 2018/10/06 06:00 PHST- 2018/04/17 00:00 [received] PHST- 2018/09/17 00:00 [revised] PHST- 2018/09/18 00:00 [accepted] PHST- 2018/10/06 06:00 [pubmed] PHST- 2020/02/15 06:00 [medline] PHST- 2018/10/06 06:00 [entrez] AID - CMC-EPUB-93443 [pii] AID - 10.2174/0929867325666181004152247 [doi] PST - ppublish SO - Curr Med Chem. 2019;26(38):6878-6895. doi: 10.2174/0929867325666181004152247.