PMID- 30289366
OWN - NLM
STAT- MEDLINE
DCOM- 20190719
LR  - 20190719
IS  - 1053-4628 (Print)
IS  - 1053-4628 (Linking)
VI  - 43
IP  - 1
DP  - 2019
TI  - Salivary Factors Related to Caries in Children with Autism.
PG  - 22-26
LID - 10.17796/1053-4625-43.1.5 [doi]
AB  - Many predisposing factors to caries are present in autism, however, it is 
      unlikely that autistic patients exhibit higher caries indexes than the rest of 
      the population. OBJECTIVE: To evaluate salivary factors related to caries in 
      autistic patients. STUDY DESIGN: 34 autistics and 34 controls aged between 4-13 
      years old were included. Decayed, missing, and filled teeth (DMFT) index and oral 
      hygiene simplified index (IHO-S) were assessed, as well as, pH, total proteins, 
      phosphate, calcium and IgA in saliva. All data were analyzed by chi(2) and 
      Student t tests for independent samples. P values<0.05 were considered 
      statistically significant. RESULTS: Autistic patients showed less caries than 
      controls (p</=0.001), DMFT was 1+/-1 and 3+/-2 respectively (p</=0.001). In relation to 
      IHO-S, values increased (p=0.008) in autistic patients (2.25+/-0.78) compared to 
      controls (1.79+/-0.59), however Salivary ph means were similar (7.20+/-0.48 and 
      7.27+/-0.34 respectively). Decreased calcium levels (p=0.013) were observed in 
      autistics (0.621+/-0.35 mmol/L) compared to controls (0.89+/-0.51 mmol/L), but 
      phosphate levels were similar (6.17+/-4.22 M, 5.51+/-4.86 M respectively). When total 
      proteins of saliva were assessed, autistics showed a slight increment (2.65+/-1.81 
      mg/mL) compared to controls (2.24+/-1.27 mg/mL) and zymography showed a higher 
      proteolytic activity in autistic children. Finally, IgA concentration reached 
      116.55+/-90.97 mug/mL in autistics and 161.61 +/- 193.37mug/mL (p=0.527) in the control 
      group. CONCLUSIONS: Even though patients with autism exhibited a poorer oral 
      hygiene, caries indexes were lower, calcium levels in saliva were found to be 
      lesser and phosphate levels higher.
FAU - Morales-Chavez, M C
AU  - Morales-Chavez MC
FAU - Villarroel-Dorrego, M
AU  - Villarroel-Dorrego M
FAU - Salas, V
AU  - Salas V
LA  - eng
PT  - Journal Article
DEP - 20181005
PL  - Singapore
TA  - J Clin Pediatr Dent
JT  - The Journal of clinical pediatric dentistry
JID - 9100079
MH  - Adolescent
MH  - *Autistic Disorder/complications
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - DMF Index
MH  - *Dental Caries/etiology
MH  - Humans
MH  - Oral Hygiene
MH  - *Saliva
OTO - NOTNLM
OT  - Autism
OT  - caries
OT  - children
OT  - saliva
EDAT- 2018/10/06 06:00
MHDA- 2019/07/20 06:00
CRDT- 2018/10/06 06:00
PHST- 2018/10/06 06:00 [pubmed]
PHST- 2019/07/20 06:00 [medline]
PHST- 2018/10/06 06:00 [entrez]
AID - 10.17796/1053-4625-43.1.5 [doi]
PST - ppublish
SO  - J Clin Pediatr Dent. 2019;43(1):22-26. doi: 10.17796/1053-4625-43.1.5. Epub 2018 
      Oct 5.