PMID- 30290669
OWN - NLM
STAT- MEDLINE
DCOM- 20181012
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 40
DP  - 2018 Oct
TI  - Association of human leukocyte antigen alleles and supertypes with immunogenicity 
      of oral rotavirus vaccine given to infants in China.
PG  - e12706
LID - 10.1097/MD.0000000000012706 [doi]
LID - e12706
AB  - Rotavirus (RV) vaccines show distinct immunogenicity in dozens of clinical 
      trials, which is associated with multiple host and environmental factors. 
      Previous research has demonstrated that the highly polymorphic human leukocyte 
      antigen (HLA) system plays an essential role in regulating immune response to a 
      variety of vaccines. This study aims to investigate the relationship between HLA 
      polymorphisms and immunogenicity of RV vaccine.A nested case-control study was 
      carried out among infants enrolled in phase III clinical trial of trivalent 
      human-lamb reassortant vaccine (RV3) in Henan province, China. Serum RV specific 
      immunoglobulin A (RV-IgA) was detected before and after a 3-dose vaccination 
      series, followed by calculation of seroconversion rates. Seroconversion was 
      defined as a 4-fold or greater increase in RV-IgA titers between pre-vaccination 
      and 1-month post-dose 3 vaccination. The infants who seroconverted were defined 
      as responders, and the others without seroconversion were considered as 
      non-responders. Their HLA genotypes were obtained by using the sequence-based 
      typing method. The HLA allele and supertype frequencies of 2 groups were analyzed 
      statistically.Eighty-three of 133 infants seroconverted after vaccination. 
      Twenty-one HLA-A, 45 HLA-B, 24 HLA-Cw, 29 HLA-DRB1 and 16 HLA-DQB1 distinct 
      alleles were detected. The frequency of HLA-B4001 (corrected P = .01, adjusted 
      OR = 0.152, 95% CI = 0.048-0.475) in non-responder group was significantly higher 
      than that in responder group. Furthermore, significant association was found 
      between HLA-B44 supertype (corrected P = .02, adjusted OR = 0.414, 95% 
      CI = 0.225-0.763) and RV non-response.Certain HLA allele (HLA-B4001) and 
      supertype (HLA-B44) are potentially associated with non-response after 
      immunization with the novel RV3 vaccine in Chinese infants.
FAU - Liu, Yueyue
AU  - Liu Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming.
AD  - National Institutes for Food and Drug Control, Beijing, China.
FAU - Guo, Tai
AU  - Guo T
AD  - National Institutes for Food and Drug Control, Beijing, China.
FAU - Yu, Qingchuan
AU  - Yu Q
AD  - National Institutes for Food and Drug Control, Beijing, China.
FAU - Zhang, Haowen
AU  - Zhang H
AD  - School of Computational Science and Engineering, Georgia Institute of Technology, 
      Atlanta, GA.
FAU - Du, Jialiang
AU  - Du J
AD  - National Institutes for Food and Drug Control, Beijing, China.
FAU - Zhang, Yunqi
AU  - Zhang Y
AD  - Yunnan University, Kunming, China.
AD  - Department of Statistics, University of Wisconsin-Madison, Madison, WI.
FAU - Xia, Shengli
AU  - Xia S
AD  - Henan Center for Disease Control and Prevention, Zhengzhou.
FAU - Yang, Huan
AU  - Yang H
AD  - Center for Drug Evaluation, Beijing, China.
FAU - Li, Qihan
AU  - Li Q
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming.
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antibodies, Viral)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Rotavirus Vaccines)
SB  - IM
MH  - Administration, Oral
MH  - Alleles
MH  - Antibodies, Viral/blood
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - Immunogenicity, Vaccine/*genetics
MH  - Immunoglobulin A/blood
MH  - Infant
MH  - Male
MH  - Rotavirus/immunology
MH  - Rotavirus Infections/*prevention & control
MH  - Rotavirus Vaccines/administration & dosage/*immunology
MH  - Seroconversion/*genetics
PMC - PMC6200448
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/10/07 06:00
MHDA- 2018/10/13 06:00
PMCR- 2018/10/05
CRDT- 2018/10/07 06:00
PHST- 2018/10/07 06:00 [entrez]
PHST- 2018/10/07 06:00 [pubmed]
PHST- 2018/10/13 06:00 [medline]
PHST- 2018/10/05 00:00 [pmc-release]
AID - 00005792-201810050-00083 [pii]
AID - MD-D-18-04823 [pii]
AID - 10.1097/MD.0000000000012706 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Oct;97(40):e12706. doi: 10.1097/MD.0000000000012706.