PMID- 30291277
OWN - NLM
STAT- MEDLINE
DCOM- 20191125
LR  - 20191125
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Oct 5
TI  - Mathematical Modeling and Analyses of Interspike-Intervals of Spontaneous 
      Activity in Afferent Neurons of the Zebrafish Lateral Line.
PG  - 14851
LID - 10.1038/s41598-018-33064-z [doi]
LID - 14851
AB  - Without stimuli, hair cells spontaneously release neurotransmitter leading to 
      spontaneous generation of action potentials (spikes) in innervating afferent 
      neurons. We analyzed spontaneous spike patterns recorded from the lateral line of 
      zebrafish and found that distributions of interspike intervals (ISIs) either have 
      an exponential shape or an "L" shape that is characterized by a sharp decay but 
      wide tail. ISI data were fitted to renewal-process models that accounted for the 
      neuron refractory periods and hair-cell synaptic release. Modeling the timing of 
      synaptic release using a mixture of two exponential distributions yielded the 
      best fit for our ISI data. Additionally, lateral line ISIs displayed positive 
      serial correlation and appeared to exhibit switching between faster and slower 
      modes of spike generation. This pattern contrasts with previous findings from the 
      auditory system where ISIs tended to have negative serial correlation due to 
      synaptic depletion. We propose that afferent neuron innervation with multiple and 
      heterogenous hair-cells synapses, each influenced by changes in calcium domains, 
      can serve as a mechanism for the random switching behavior. Overall, our analyses 
      provide evidence of how physiological similarities and differences between 
      synapses and innervation patterns in the auditory, vestibular, and lateral line 
      systems can lead to variations in spontaneous activity.
FAU - Song, Sangmin
AU  - Song S
AD  - Department of Biology and Neuroscience Program, Amherst College, Amherst, MA, 
      01002, USA.
FAU - Lee, Ji Ah
AU  - Lee JA
AD  - Department of Mathematics and Statistics, Smith College, Northampton, MA, 01063, 
      USA.
FAU - Kiselev, Ilya
AU  - Kiselev I
AD  - Department of Biology and Neuroscience Program, Amherst College, Amherst, MA, 
      01002, USA.
FAU - Iyengar, Varun
AU  - Iyengar V
AD  - Department of Biology and Neuroscience Program, Amherst College, Amherst, MA, 
      01002, USA.
FAU - Trapani, Josef G
AU  - Trapani JG
AUID- ORCID: 0000-0002-6898-649X
AD  - Department of Biology and Neuroscience Program, Amherst College, Amherst, MA, 
      01002, USA.
FAU - Tania, Nessy
AU  - Tania N
AUID- ORCID: 0000-0003-4256-2434
AD  - Department of Mathematics and Statistics, Smith College, Northampton, MA, 01063, 
      USA. ntania@smith.edu.
LA  - eng
GR  - R15 DC014843/DC/NIDCD NIH HHS/United States
GR  - NSF UBM-1129194/National Science Foundation (NSF)/International
GR  - NIH R15DC014843/U.S. Department of Health & Human Services | NIH | National 
      Institute on Deafness and Other Communication Disorders (NIDCD)/International
GR  - 355461/Simons Foundation/International
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20181005
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - *Action Potentials
MH  - Animals
MH  - Lateral Line System/cytology/*innervation/physiology
MH  - Models, Neurological
MH  - Neurons, Afferent/cytology/*physiology
MH  - Synapses/physiology
MH  - Zebrafish/*physiology
PMC - PMC6173758
COIS- The authors declare no competing interests.
EDAT- 2018/10/07 06:00
MHDA- 2019/11/26 06:00
PMCR- 2018/10/05
CRDT- 2018/10/07 06:00
PHST- 2017/09/01 00:00 [received]
PHST- 2018/09/21 00:00 [accepted]
PHST- 2018/10/07 06:00 [entrez]
PHST- 2018/10/07 06:00 [pubmed]
PHST- 2019/11/26 06:00 [medline]
PHST- 2018/10/05 00:00 [pmc-release]
AID - 10.1038/s41598-018-33064-z [pii]
AID - 33064 [pii]
AID - 10.1038/s41598-018-33064-z [doi]
PST - epublish
SO  - Sci Rep. 2018 Oct 5;8(1):14851. doi: 10.1038/s41598-018-33064-z.