PMID- 30291524
OWN - NLM
STAT- MEDLINE
DCOM- 20190529
LR  - 20221117
IS  - 1572-8781 (Electronic)
IS  - 1387-2176 (Linking)
VI  - 20
IP  - 4
DP  - 2018 Oct 5
TI  - Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO).
PG  - 86
LID - 10.1007/s10544-018-0335-z [doi]
AB  - While extracorporeal membrane oxygenation (ECMO) is a valuable therapy for 
      patients with lung or heart failure, clinical use of ECMO remains limited due to 
      hemocompatibility concerns with pro-coagulatory hollow fiber membrane geometries. 
      Previously, we demonstrated the feasibility of silicon nanopore (SNM) and 
      micropore (SmuM) membranes for transport between two liquid-phase compartments in 
      blood-contacting devices. Herein, we investigate various pore sizes of SNM and 
      SmuM membranes - alone or with a polydimethylsiloxane (PDMS) protective coating - 
      for parameters that determine suitability for gas exchange. We characterized the 
      bubble or rupture point of these membranes to determine sweep gas pressures at 
      which gas emboli would form. The smallest pore size SNM and the SmuM with PDMS 
      coating could be pressurized in excess of 260 cmHg without rupture, which is 
      comparable to hollow fiber sweep gas pressures. Oxygen flux for the SmuM with and 
      without PDMS was insignificantly different at 0.0306 +/- 0.0028 and 
      0.0297 +/- 0.0012 mL/min, respectively, while SNM flux was significantly lower at 
      0.0149 +/- 0.0040 mL/min. However, the area-normalized mass transfer coefficient of 
      the SNM was 338 +/- 54 mL O(2) m(-2) min(-1) cmHg(-1) - an order of magnitude 
      higher than that of the SmuM with and without PDMS (57.3 +/- 5.5 and 55.6 +/- 2.2 mL 
      O(2) m(-2) min(-1) cmHg(-1)). Ultimately, we conclude that SmuM-PDMS may make 
      effective membranes for ECMO, since they are both mechanically robust and capable 
      of high oxygen flux.
FAU - Abada, Emily N
AU  - Abada EN
AUID- ORCID: 0000-0001-9037-5583
AD  - Department of Bioengineering and Therapeutic Sciences, University of California, 
      1700 4th St, QB3 Byers Hall Rm 203A, San Francisco, CA, 94158, USA. 
      shuvo.roy@ucsf.edu.
FAU - Feinberg, Benjamin J
AU  - Feinberg BJ
AD  - Department of Bioengineering and Therapeutic Sciences, University of California, 
      1700 4th St, QB3 Byers Hall Rm 203A, San Francisco, CA, 94158, USA.
FAU - Roy, Shuvo
AU  - Roy S
AD  - Department of Bioengineering and Therapeutic Sciences, University of California, 
      1700 4th St, QB3 Byers Hall Rm 203A, San Francisco, CA, 94158, USA.
LA  - eng
GR  - U54HL119893/HL/NHLBI NIH HHS/United States
GR  - UL1 TR001872/TR/NCATS NIH HHS/United States
GR  - P50 FD003793/FD/FDA HHS/United States
GR  - P50 FD00379/U.S. Food and Drug Administration/International
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20181005
PL  - United States
TA  - Biomed Microdevices
JT  - Biomedical microdevices
JID - 100887374
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Membranes, Artificial)
RN  - 63148-62-9 (baysilon)
RN  - Z4152N8IUI (Silicon)
SB  - IM
MH  - Dimethylpolysiloxanes/chemistry
MH  - Extracorporeal Membrane Oxygenation/*methods
MH  - *Membranes, Artificial
MH  - Permeability
MH  - Porosity
MH  - Silicon/*chemistry
OTO - NOTNLM
OT  - Bubble point
OT  - ECMO
OT  - Extracorporeal membrane oxygenation
OT  - MEMS
OT  - PDMS
OT  - Silicon membrane
EDAT- 2018/10/07 06:00
MHDA- 2019/05/30 06:00
CRDT- 2018/10/07 06:00
PHST- 2018/10/07 06:00 [entrez]
PHST- 2018/10/07 06:00 [pubmed]
PHST- 2019/05/30 06:00 [medline]
AID - 10.1007/s10544-018-0335-z [pii]
AID - 10.1007/s10544-018-0335-z [doi]
PST - epublish
SO  - Biomed Microdevices. 2018 Oct 5;20(4):86. doi: 10.1007/s10544-018-0335-z.