PMID- 30295324
OWN - NLM
STAT- MEDLINE
DCOM- 20190711
LR  - 20190711
IS  - 1600-0765 (Electronic)
IS  - 0022-3484 (Linking)
VI  - 54
IP  - 2
DP  - 2019 Apr
TI  - The periodontal stem/progenitor cell inflammatory-regenerative cross talk: A new 
      perspective.
PG  - 81-94
LID - 10.1111/jre.12616 [doi]
AB  - Adult multipotent stem/progenitor cells, with remarkable regenerative potential, 
      have been isolated from various components of the human periodontium. These 
      multipotent stem/progenitor cells include the periodontal ligament 
      stem/progenitor cells (PDLSCs), stem cells from the apical papilla (SCAP), the 
      gingival mesenchymal stem/progenitor cells (G-MSCs), and the alveolar bone proper 
      stem/progenitor cells (AB-MSCs). Whereas inflammation is regarded as the reason 
      for tissue damage, it also remains a fundamental step of any early healing 
      process. In performing their periodontal tissue regenerative/reparative activity, 
      periodontal stem/progenitor cells interact with their surrounding inflammatory 
      micro-environmental, through their expressed receptors, which could influence 
      their fate and the outcome of any periodontal stem/progenitor cell-mediated 
      reparative/regenerative activity. The present review discusses the current 
      understanding about the interaction of periodontal stem/progenitor cells with 
      their surrounding inflammatory micro-environment, elaborates on the inflammatory 
      factors influencing their stemness, proliferation, migration/homing, 
      differentiation, and immunomodulatory attributes, the possible underlying 
      intracellular mechanisms, as well as their proposed relationship to the canonical 
      and noncanonical Wnt pathways.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Fawzy El-Sayed, Karim M
AU  - Fawzy El-Sayed KM
AUID- ORCID: 0000-0002-6261-3609
AD  - Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, 
      Cairo University, Cairo, Egypt.
AD  - Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, 
      Christian Albrechts University, Kiel, Germany.
FAU - Elahmady, Maryam
AU  - Elahmady M
AD  - Faculty of Dentistry, New Giza University, Giza, Egypt.
FAU - Adawi, Zeina
AU  - Adawi Z
AD  - Faculty of Dentistry, New Giza University, Giza, Egypt.
FAU - Aboushadi, Nour
AU  - Aboushadi N
AD  - Faculty of Dentistry, New Giza University, Giza, Egypt.
FAU - Elnaggar, Ali
AU  - Elnaggar A
AD  - Faculty of Dentistry, New Giza University, Giza, Egypt.
FAU - Eid, Maryam
AU  - Eid M
AD  - Faculty of Dentistry, New Giza University, Giza, Egypt.
FAU - Hamdy, Nayera
AU  - Hamdy N
AD  - Faculty of Dentistry, New Giza University, Giza, Egypt.
FAU - Sanaa, Dalia
AU  - Sanaa D
AD  - Faculty of Dentistry, New Giza University, Giza, Egypt.
FAU - Dorfer, Christof E
AU  - Dorfer CE
AD  - Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, 
      Christian Albrechts University, Kiel, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181008
PL  - United States
TA  - J Periodontal Res
JT  - Journal of periodontal research
JID - 0055107
SB  - IM
MH  - Alveolar Process/cytology
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Gingiva/cytology
MH  - Humans
MH  - Immunomodulation
MH  - Inflammation/*pathology/*physiopathology
MH  - *Multipotent Stem Cells/pathology/physiology
MH  - Periodontal Ligament/cytology
MH  - Periodontium/*cytology/pathology/*physiology
MH  - *Regeneration
MH  - *Stem Cells/pathology/physiology
MH  - Tooth Apex/cytology
MH  - Wnt Signaling Pathway/physiology
OTO - NOTNLM
OT  - inflammation
OT  - periodontium
OT  - regeneration
OT  - stem cells
EDAT- 2018/10/09 06:00
MHDA- 2019/07/12 06:00
CRDT- 2018/10/09 06:00
PHST- 2018/06/09 00:00 [received]
PHST- 2018/07/24 00:00 [revised]
PHST- 2018/08/31 00:00 [accepted]
PHST- 2018/10/09 06:00 [pubmed]
PHST- 2019/07/12 06:00 [medline]
PHST- 2018/10/09 06:00 [entrez]
AID - 10.1111/jre.12616 [doi]
PST - ppublish
SO  - J Periodontal Res. 2019 Apr;54(2):81-94. doi: 10.1111/jre.12616. Epub 2018 Oct 8.