PMID- 30295349 OWN - NLM STAT- MEDLINE DCOM- 20200601 LR - 20200601 IS - 1098-1063 (Electronic) IS - 1050-9631 (Linking) VI - 29 IP - 6 DP - 2019 Jun TI - Spatial object recognition memory formation under acute stress. PG - 491-499 LID - 10.1002/hipo.23037 [doi] AB - Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recognition (SOR) training, which only induces a short-term memory (STM), promoted the formation of SOR-long term memory (SOR-LTM) in rats. The effect induced by stress was dependent on the activation of glucocorticoid- and mineralocorticoid-receptors, brain-derived neurotrophic factor (BDNF) and protein synthesis in the dorsal hippocampus. In contrast, EP after a strong SOR impaired SOR-LTM probably by interfering with the use of necessary resources. Moreover, we show that the EP session before training induced anterograde interference, which it was not reversed by a subsequent exposure to an open field. Our findings provide novel insights into the impact of stress on LTM formation in rodents and they are discussed under the behavioral analogue of the synaptic tagging and capture hypothesis. CI - (c) 2018 Wiley Periodicals, Inc. FAU - Lopes da Cunha, Pamela AU - Lopes da Cunha P AD - Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. AD - Instituto de Biologia Celular y Neurociencias "Dr Eduardo De Robertis" (IBCN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina. FAU - Villar, Maria Eugenia AU - Villar ME AD - Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. AD - Instituto de Biologia Celular y Neurociencias "Dr Eduardo De Robertis" (IBCN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina. FAU - Ballarini, Fabricio AU - Ballarini F AD - Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. AD - Instituto de Biologia Celular y Neurociencias "Dr Eduardo De Robertis" (IBCN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina. FAU - Tintorelli, Ramiro AU - Tintorelli R AD - Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. AD - Instituto de Biologia Celular y Neurociencias "Dr Eduardo De Robertis" (IBCN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina. FAU - Ana Maria Viola, Haydee AU - Ana Maria Viola H AUID- ORCID: 0000-0003-4230-4451 AD - Instituto de Biologia Celular y Neurociencias "Dr Eduardo De Robertis" (IBCN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina. AD - Departamento de Fisiologia, Biologia Molecular y Celular "Dr. Hector Maldonado" (FBMC), Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina. LA - eng GR - PICT 2012-1035/Agencia Nacional de Promocion Cientifica y Tecnologica/International GR - PIP 00366/Consejo Nacional de Investigaciones Cientificas y Tecnicas/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181122 PL - United States TA - Hippocampus JT - Hippocampus JID - 9108167 RN - 0 (Bdnf protein, rat) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Receptors, Glucocorticoid) RN - 0 (Receptors, Mineralocorticoid) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/physiology MH - Hippocampus/*physiology MH - Male MH - Memory, Long-Term/*physiology MH - Memory, Short-Term/physiology MH - Rats MH - Rats, Wistar MH - Receptors, Glucocorticoid/physiology MH - Receptors, Mineralocorticoid/physiology MH - Recognition, Psychology/*physiology MH - Spatial Learning/physiology MH - Spatial Memory/physiology MH - Stress, Physiological/*physiology OTO - NOTNLM OT - elevated platform OT - hippocampus OT - long-term memory OT - spatial object recognition OT - synaptic tagging EDAT- 2018/10/09 06:00 MHDA- 2020/06/02 06:00 CRDT- 2018/10/09 06:00 PHST- 2018/01/29 00:00 [received] PHST- 2018/09/12 00:00 [revised] PHST- 2018/09/17 00:00 [accepted] PHST- 2018/10/09 06:00 [pubmed] PHST- 2020/06/02 06:00 [medline] PHST- 2018/10/09 06:00 [entrez] AID - 10.1002/hipo.23037 [doi] PST - ppublish SO - Hippocampus. 2019 Jun;29(6):491-499. doi: 10.1002/hipo.23037. Epub 2018 Nov 22.