PMID- 30296291
OWN - NLM
STAT- MEDLINE
DCOM- 20190405
LR  - 20190405
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 10
DP  - 2018
TI  - Three-dimensional holographic visualization of high-resolution myocardial scar on 
      HoloLens.
PG  - e0205188
LID - 10.1371/journal.pone.0205188 [doi]
LID - e0205188
AB  - Visualization of the complex 3D architecture of myocardial scar could improve 
      guidance of radio-frequency ablation in the treatment of ventricular tachycardia 
      (VT). In this study, we sought to develop a framework for 3D holographic 
      visualization of myocardial scar, imaged using late gadolinium enhancement (LGE), 
      on the augmented reality HoloLens. 3D holographic LGE model was built using the 
      high-resolution 3D LGE image. Smooth endo/epicardial surface meshes were 
      generated using Poisson surface reconstruction. For voxel-wise 3D scar model, 
      every scarred voxel was rendered into a cube which carries the actual resolution 
      of the LGE sequence. For surface scar model, scar information was projected on 
      the endocardial surface mesh. Rendered layers were blended with different 
      transparency and color, and visualized on HoloLens. A pilot animal study was 
      performed where 3D holographic visualization of the scar was performed in 5 
      swines who underwent controlled infarction and electroanatomic mapping to 
      identify VT substrate. 3D holographic visualization enabled assessment of the 
      complex 3D scar architecture with touchless interaction in a sterile environment. 
      Endoscopic view allowed visualization of scar from the ventricular chambers. Upon 
      completion of the animal study, operator and mapping specialist independently 
      completed the perceived usefulness questionnaire in the six-item usefulness 
      scale. Operator and mapping specialist found it useful (usefulness rating: 
      operator, 5.8; mapping specialist, 5.5; 1-7 scale) to have scar information 
      during the intervention. HoloLens 3D LGE provides a true 3D perception of the 
      complex scar architecture with immersive experience to visualize scar in an 
      interactive and interpretable 3D approach, which may facilitate MR-guided VT 
      ablation.
FAU - Jang, Jihye
AU  - Jang J
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
AD  - Department of Computer Science, Technical University of Munich, Munich, Germany.
FAU - Tschabrunn, Cory M
AU  - Tschabrunn CM
AD  - Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, 
      PA, United States of America.
FAU - Barkagan, Michael
AU  - Barkagan M
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Anter, Elad
AU  - Anter E
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
FAU - Menze, Bjoern
AU  - Menze B
AD  - Department of Computer Science, Technical University of Munich, Munich, Germany.
FAU - Nezafat, Reza
AU  - Nezafat R
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center and Harvard Medical School, Boston, MA, United States of America.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20181008
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Animals
MH  - Catheter Ablation/*methods
MH  - Cicatrix/*diagnostic imaging/etiology/surgery
MH  - Contrast Media/administration & dosage
MH  - Disease Models, Animal
MH  - Endoscopy/methods
MH  - Epicardial Mapping
MH  - Feasibility Studies
MH  - Gadolinium/administration & dosage
MH  - Heart Ventricles/diagnostic imaging/pathology/surgery
MH  - Holography/*methods
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Myocardial Infarction/*complications
MH  - Pilot Projects
MH  - Swine
MH  - Tachycardia, Ventricular/etiology/pathology/*surgery
PMC - PMC6175509
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/10/09 06:00
MHDA- 2019/04/06 06:00
PMCR- 2018/10/08
CRDT- 2018/10/09 06:00
PHST- 2018/04/02 00:00 [received]
PHST- 2018/08/28 00:00 [accepted]
PHST- 2018/10/09 06:00 [entrez]
PHST- 2018/10/09 06:00 [pubmed]
PHST- 2019/04/06 06:00 [medline]
PHST- 2018/10/08 00:00 [pmc-release]
AID - PONE-D-18-09851 [pii]
AID - 10.1371/journal.pone.0205188 [doi]
PST - epublish
SO  - PLoS One. 2018 Oct 8;13(10):e0205188. doi: 10.1371/journal.pone.0205188. 
      eCollection 2018.