PMID- 30296556
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20190215
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 184
DP  - 2019 Jan 1
TI  - Ventral striatum links motivational and motor networks during operant-conditioned 
      movement in rats.
PG  - 943-953
LID - S1053-8119(18)31977-3 [pii]
LID - 10.1016/j.neuroimage.2018.10.018 [doi]
AB  - Voluntary actions require motives. It is already known that the medial prefrontal 
      cortex (MPFC) assess the motivational values. However, it remains unclear how the 
      motivational process gains access to the motor execution system in the brain. 
      Here we present evidence that the ventral striatum (VS) plays a hub-like role in 
      mediating motivational and motor processing in operant behavior. We used positron 
      emission tomography (PET) to detect the neural activation areas associated with 
      motivational action. Using obtained regions, partial correlation analysis was 
      performed to examine how the motivational signals propagate to the motor system. 
      The results revealed that VS activity propagated to both MPFC and primary motor 
      cortex through the thalamus. Moreover, muscimol injection into the VS suppressed 
      the motivational behavior, supporting the idea of representations of motivational 
      signals in VS that trigger motivational behavior. These results suggest that the 
      VS-thalamic pathway plays a pivotal role for both motivational processing through 
      interactions with the MPFC and for motor processing through interactions with the 
      motor BG circuits.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Hori, Yuki
AU  - Hori Y
AD  - Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National 
      Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan; 
      Department of Functional Brain Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan.
FAU - Ihara, Naoki
AU  - Ihara N
AD  - Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National 
      Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan; 
      Department of Functional Brain Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan.
FAU - Sugai, Chiaki
AU  - Sugai C
AD  - Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National 
      Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan; 
      Department of Functional Brain Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan.
FAU - Ogura, Jun
AU  - Ogura J
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan.
FAU - Honda, Manabu
AU  - Honda M
AD  - Department of Functional Brain Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan.
FAU - Kato, Koichi
AU  - Kato K
AD  - Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National 
      Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan; 
      Department of Functional Brain Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan.
FAU - Isomura, Yoshikazu
AU  - Isomura Y
AD  - Brain Science Institute, Tamagawa University, Machida City, Tokyo 194-8610, 
      Japan.
FAU - Hanakawa, Takashi
AU  - Hanakawa T
AD  - Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National 
      Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan; 
      Department of Functional Brain Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Kodaira City, Tokyo 187-8551, Japan. 
      Electronic address: hanakawa@ncnp.go.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181005
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Animals
MH  - Conditioning, Operant
MH  - Male
MH  - Motivation/*physiology
MH  - Motor Cortex/*metabolism
MH  - *Movement
MH  - Neural Pathways/metabolism
MH  - Positron-Emission Tomography
MH  - Rats, Long-Evans
MH  - Thalamus/metabolism
MH  - Ventral Striatum/*metabolism
OTO - NOTNLM
OT  - (18)F-FDG PET
OT  - Brain connectivity
OT  - Motivation
OT  - Operant behavior
OT  - Ventral striatum
EDAT- 2018/10/09 06:00
MHDA- 2019/02/05 06:00
CRDT- 2018/10/09 06:00
PHST- 2018/07/10 00:00 [received]
PHST- 2018/09/09 00:00 [revised]
PHST- 2018/10/04 00:00 [accepted]
PHST- 2018/10/09 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2018/10/09 06:00 [entrez]
AID - S1053-8119(18)31977-3 [pii]
AID - 10.1016/j.neuroimage.2018.10.018 [doi]
PST - ppublish
SO  - Neuroimage. 2019 Jan 1;184:943-953. doi: 10.1016/j.neuroimage.2018.10.018. Epub 
      2018 Oct 5.