PMID- 30297786
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20191008
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Oct 8
TI  - Electrophysiological evidence for abnormal glutamate-GABA association following 
      psychosis onset.
PG  - 211
LID - 10.1038/s41398-018-0261-0 [doi]
LID - 211
AB  - Previous studies have shown glutamatergic dysfunction and gamma-aminobutyric acid 
      (GABA)-ergic dysfunction in schizophrenia. Animal studies suggest that 
      N-methyl-D-aspartate receptor (NMDAR) dysfunction and GABA-ergic dysfunction 
      interact with each other and lead to alterations in excitatory/inhibitory 
      balance. The NMDAR and GABAergic-interneuron functions may be indexed by mismatch 
      negativity (MMN) and auditory steady-state gamma-band response (ASSR), 
      respectively. However, no previous studies have tested the hypothesis of an 
      abnormal association between MMN and gamma-band ASSR in the same patients to 
      identify the in vivo evidence of NMDAR-GABA association during the early stages 
      of psychosis. Participants were individuals with recent-onset schizophrenia 
      (ROSZ; N = 21), ultra-high risk (UHR; N = 27), and healthy controls (HCs; 
      N = 24). The MMN amplitude was significantly impaired in ROSZ (p = 0.001, 
      d = 1.20) and UHR (p = 0.003, d = 1.01) compared with HCs. The intertrial phase 
      coherence (ITC) index of gamma-band ASSR was significantly reduced in ROSZ 
      compared with HCs (p < 0.001, d = -1.27) and UHR (p = 0.032, d = -0.75). The 
      event-related spectral perturbation (ERSP) index of gamma-band ASSR was 
      significantly smaller in ROSZ compared with HCs (p < 0.001, d = -1.21). The MMN 
      amplitude was significantly correlated with the ITC in ROSZ (r = -0.69, 
      p < 0.001). These findings provide the first in vivo evidence that an abnormal 
      association of the electrophysiological indices of NMDAR and GABA dysfunctions 
      may be present in recent-onset schizophrenia.
FAU - Koshiyama, Daisuke
AU  - Koshiyama D
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Kirihara, Kenji
AU  - Kirihara K
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Tada, Mariko
AU  - Tada M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
AD  - The International Research Center for Neurointelligence (WPI-IRCN) at The 
      University of Tokyo Institutes for Advanced Study (UTIAS), The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Nagai, Tatsuya
AU  - Nagai T
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
AD  - Department of Psychiatry, Kawamuro Memorial Hospital, 71, Kitashinbo, Joetsu-shi, 
      Niigata, 943-0109, Japan.
FAU - Fujioka, Mao
AU  - Fujioka M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Ichikawa, Eriko
AU  - Ichikawa E
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Ohta, Kazusa
AU  - Ohta K
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Tani, Motoko
AU  - Tani M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Tsuchiya, Maiko
AU  - Tsuchiya M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Kanehara, Akiko
AU  - Kanehara A
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Morita, Kentaro
AU  - Morita K
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Sawada, Kingo
AU  - Sawada K
AUID- ORCID: 0000-0002-4662-0294
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Matsuoka, Jun
AU  - Matsuoka J
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Satomura, Yoshihiro
AU  - Satomura Y
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Koike, Shinsuke
AU  - Koike S
AUID- ORCID: 0000-0002-3375-236X
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
AD  - The International Research Center for Neurointelligence (WPI-IRCN) at The 
      University of Tokyo Institutes for Advanced Study (UTIAS), The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
AD  - University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), 
      3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
AD  - Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, 
      The University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
FAU - Suga, Motomu
AU  - Suga M
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
AD  - Department of Rehabilitation, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Araki, Tsuyoshi
AU  - Araki T
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
FAU - Kasai, Kiyoto
AU  - Kasai K
AD  - Department of Neuropsychiatry, Graduate School of Medicine, The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. kasaik-tky@umin.net.
AD  - The International Research Center for Neurointelligence (WPI-IRCN) at The 
      University of Tokyo Institutes for Advanced Study (UTIAS), The University of 
      Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. kasaik-tky@umin.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181008
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Brain/*physiopathology
MH  - Electroencephalography
MH  - *Evoked Potentials, Auditory
MH  - Female
MH  - Gamma Rhythm
MH  - Glutamic Acid/*physiology
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/complications/*physiopathology
MH  - Schizophrenia/complications/*physiopathology
MH  - Young Adult
MH  - gamma-Aminobutyric Acid/*physiology
PMC - PMC6175929
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/10/10 06:00
MHDA- 2019/04/02 06:00
PMCR- 2018/10/08
CRDT- 2018/10/10 06:00
PHST- 2018/03/01 00:00 [received]
PHST- 2018/09/07 00:00 [accepted]
PHST- 2018/07/26 00:00 [revised]
PHST- 2018/10/10 06:00 [entrez]
PHST- 2018/10/10 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/10/08 00:00 [pmc-release]
AID - 10.1038/s41398-018-0261-0 [pii]
AID - 261 [pii]
AID - 10.1038/s41398-018-0261-0 [doi]
PST - epublish
SO  - Transl Psychiatry. 2018 Oct 8;8(1):211. doi: 10.1038/s41398-018-0261-0.