PMID- 30298107
OWN - NLM
STAT- MEDLINE
DCOM- 20190703
LR  - 20221207
IS  - 2090-0716 (Electronic)
IS  - 2090-0708 (Print)
IS  - 2090-0708 (Linking)
VI  - 2018
DP  - 2018
TI  - Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in 
      African Males with or without Type 2 Diabetes Mellitus.
PG  - 7461903
LID - 10.1155/2018/7461903 [doi]
LID - 7461903
AB  - BACKGROUND: Fibroblast growth factor-21 is an endocrine regulator with 
      therapeutic and diagnostic potential. The levels and pattern of circulating 
      FGF-21 have been described mainly in European and Asian populations. Given its 
      strong association with adiposity, and the reported ethnic variabilities in body 
      composition, examining FGF-21 in an African population is crucial. METHODS: We 
      measured levels of circulating FGF-21 in 207 overweight and obese Tanzanian males 
      with or without type 2 diabetes mellitus (T2DM), and using statistical 
      approaches, we explored their relationship with anthropometric and biochemical 
      parameters. RESULTS: Consistent with previous reports from European and Asian 
      populations, we found higher levels of FGF-21 in people with T2DM compared to 
      those without the disease. Based on statistical models, measures of adiposity 
      explained up to 59% of the variability in FGF-21 levels in the circulation. 
      CONCLUSION: Levels of circulating FGF-21 in overweight and obese African males 
      are higher in T2DM and strongly correlate with measures of adiposity.
FAU - Mashili, Fredirick L
AU  - Mashili FL
AUID- ORCID: 0000-0002-5306-6703
AD  - Department of Physiology, Muhimbili University of Health and Allied Sciences, Box 
      65001, Dar es Salaam, Tanzania.
FAU - Ramaiya, Kaushik
AU  - Ramaiya K
AD  - Tanzania Diabetes Association, Box 65201, Dar Es Salaam, Tanzania.
FAU - Lutale, Janet
AU  - Lutale J
AD  - Department of Physiology, Muhimbili University of Health and Allied Sciences, Box 
      65001, Dar es Salaam, Tanzania.
FAU - Njelekela, Marina
AU  - Njelekela M
AUID- ORCID: 0000-0002-1536-2878
AD  - Tanzania Diabetes Association, Box 65201, Dar Es Salaam, Tanzania.
FAU - Francis, Filbert
AU  - Francis F
AD  - National Institute of Medical Research, Box 5004, Tanga, Tanzania.
FAU - Zierath, Juleen
AU  - Zierath J
AD  - Department of Physiology and Pharmacology, SE-17177 Stockholm, Sweden.
FAU - Krook, Anna
AU  - Krook A
AD  - Department of Physiology and Pharmacology, SE-17177 Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180912
PL  - United States
TA  - J Obes
JT  - Journal of obesity
JID - 101526295
RN  - 0 (fibroblast growth factor 21)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - *Adiposity
MH  - Black People
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fibroblast Growth Factors/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood
MH  - Overweight/blood
MH  - Tanzania
PMC - PMC6157203
EDAT- 2018/10/10 06:00
MHDA- 2019/07/04 06:00
PMCR- 2018/09/12
CRDT- 2018/10/10 06:00
PHST- 2018/05/14 00:00 [received]
PHST- 2018/08/07 00:00 [revised]
PHST- 2018/08/13 00:00 [accepted]
PHST- 2018/10/10 06:00 [entrez]
PHST- 2018/10/10 06:00 [pubmed]
PHST- 2019/07/04 06:00 [medline]
PHST- 2018/09/12 00:00 [pmc-release]
AID - 10.1155/2018/7461903 [doi]
PST - epublish
SO  - J Obes. 2018 Sep 12;2018:7461903. doi: 10.1155/2018/7461903. eCollection 2018.