PMID- 30298507
OWN - NLM
STAT- MEDLINE
DCOM- 20190328
LR  - 20190328
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 35
IP  - 5
DP  - 2018 Oct 10
TI  - [Preliminary analysis of genetics and clinical features of patients with acute 
      myeloid leukemia and near-tetraploid/tetraploidy karyotype].
PG  - 733-736
LID - 10.3760/cma.j.issn.1003-9406.2018.05.026 [doi]
AB  - OBJECTIVE: To explore the genetic and clinical features of patients with acute 
      myeloid leukemia (AML) and near-tetraploidy/tetraploidy (NT/T) karyotype. 
      METHODS: Cytogenetic findings of 1836 cases of primary AML were retrospectively 
      analyzed. Karyotypes of the identified cases were confirmed by fluorescence in 
      situ hybridization (FISH). Clinical data including gender, age, morphology, 
      immunophenotype, genetics, and prognosis were reviewed. RESULTS: Nine male and 
      two female patients with NT/T were identified with a median age of 63 years. 
      Microscopically, the patients were characterized by large blasts and irregular 
      nuclear contours. All patients expressed CD34, and nine of them expressed HLA-DR. 
      Ten patients had complete remission during the first course of treatment. One 
      patient showed primary drug resistance. CONCLUSION: NT/T AML primarily occurs in 
      elder males and has a characteristic morphology and genetics. The prognosis is 
      better than AML patients with complex karyotypes.
FAU - He, Xuchun
AU  - He X
AD  - Fujian Health College, Fuzhou, Fujian 350101, China. csuchenjiadi@163.com.
FAU - Chen, Jiadi
AU  - Chen J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Karyotype
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Tetraploidy
EDAT- 2018/10/10 06:00
MHDA- 2019/03/29 06:00
CRDT- 2018/10/10 06:00
PHST- 2018/10/10 06:00 [entrez]
PHST- 2018/10/10 06:00 [pubmed]
PHST- 2019/03/29 06:00 [medline]
AID - 940635153 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2018.05.026 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Oct 10;35(5):733-736. doi: 
      10.3760/cma.j.issn.1003-9406.2018.05.026.