PMID- 30300266
OWN - NLM
STAT- MEDLINE
DCOM- 20210205
LR  - 20221207
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 40
IP  - 1
DP  - 2020 Jan
TI  - RELATIONSHIP BETWEEN STAGES OF DIABETIC RETINOPATHY AND LEVELS OF BRAIN-DERIVED 
      NEUROTROPHIC FACTOR IN AQUEOUS HUMOR AND SERUM.
PG  - 121-125
LID - 10.1097/IAE.0000000000002355 [doi]
AB  - PURPOSE: The aim of the study was to determine aqueous humor and serum levels of 
      brain-derived neurotrophic factor (BDNF) in diabetic patients with and without 
      retinopathy. METHODS: The study included diabetic patients with or without 
      retinopathy, who had an indication for cataract surgery. The study groups were 
      diabetic patients without retinopathy (Group 2), with nonproliferative diabetic 
      retinopathy (Group 3), and with proliferative retinopathy (Group 4). To 
      quantitatively determine the amount of BDNF in samples, the RayBio Human BDNF 
      ELISA kit (Norcross, GA), based on an enzyme-labeled immunosorbent assay was 
      used. RESULTS: The median serum BDNF levels were significantly lower in all the 
      study groups than in the control group (P values: 0.038 Group 2, 0.02 Group 3, 
      and 0.002 Group 4). Serum BDNF was lower in Group 4 than in Group 3 (P = 0.030), 
      and in Group 3 than in Group 2 (P = 0.04). The median aqueous humor BDNF levels 
      were significantly decreased in all groups (P values: 0.047 Group 2, 0.021 Group 
      3, and 0.007 Group 4). There was no significant difference between Groups 2, 3, 
      and 4 (P = 0.214). CONCLUSION: The serum and aqueous humor BDNF levels decreased 
      in patients with diabetes mellitus (DM) before the emergence of clinical signs of 
      retinopathy.
FAU - Taslipinar Uzel, Ayse Guzin
AU  - Taslipinar Uzel AG
AD  - Department of Ophthalmology, Afyonkarahisar Sandikli State Hospital, 
      Afyonkarahisar, Turkey.
FAU - UGurlu, Nagihan
AU  - UGurlu N
AD  - Department of Ophthalmology, Ataturk Education and Research Hospital, Yildirim 
      Beyazit University, Ankara, Turkey.
FAU - Toklu, Yasin
AU  - Toklu Y
AD  - Department of Ophthalmology, Ataturk Education and Research Hospital, Yildirim 
      Beyazit University, Ankara, Turkey.
FAU - CIcek, Muharrem
AU  - CIcek M
AD  - Department of Microbiology, Hacettepe University, Ankara, Turkey; and.
FAU - Boral, Baris
AU  - Boral B
AD  - Department of Immunology, Cukurova University, Adana, Turkey.
FAU - Sener, Burcin
AU  - Sener B
AD  - Department of Microbiology, Hacettepe University, Ankara, Turkey; and.
FAU - CaGil, Nurullah
AU  - CaGil N
AD  - Department of Ophthalmology, Ataturk Education and Research Hospital, Yildirim 
      Beyazit University, Ankara, Turkey.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aqueous Humor/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cataract Extraction
MH  - Chromatography, High Pressure Liquid
MH  - Diabetes Mellitus, Type 2/blood
MH  - Diabetic Retinopathy/*blood/classification
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2018/10/10 06:00
MHDA- 2021/02/07 06:00
CRDT- 2018/10/10 06:00
PHST- 2018/10/10 06:00 [pubmed]
PHST- 2021/02/07 06:00 [medline]
PHST- 2018/10/10 06:00 [entrez]
AID - 00006982-202001000-00015 [pii]
AID - 10.1097/IAE.0000000000002355 [doi]
PST - ppublish
SO  - Retina. 2020 Jan;40(1):121-125. doi: 10.1097/IAE.0000000000002355.