PMID- 30300654
OWN - NLM
STAT- MEDLINE
DCOM- 20181214
LR  - 20181214
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 212
DP  - 2018 Nov 1
TI  - Differential effects of high-fat diets before pregnancy and/or during pregnancy 
      on fetal growth development.
PG  - 241-250
LID - S0024-3205(18)30625-8 [pii]
LID - 10.1016/j.lfs.2018.10.008 [doi]
AB  - AIMS: The aim of the study was to investigate the effects of high-fat diets 
      before pregnancy and/or during pregnancy on fetal development. MAIN METHODS: 
      Female mice were fed with standard diets (SD) or high-fat diets (HFD). After 
      12 weeks, females were mated. In the SD + SD and HFD + SD groups, pregnant mice 
      were fed with standard diets. In the SD + HFD and HFD + HFD groups, pregnant mice 
      were fed with high-fat diets. All pregnant mice were sacrificed on gestational 
      day (GD) 16. KEY FINDINGS: Fetal weight and crown-rump length were increased in 
      SD + HFD-fed mice, whereas were decreased in HFD + SD-fed mice. The levels of CRP 
      and TNF-alpha in maternal serum and amniotic fluid were elevated in all HFD-fed mice. 
      Placenta weight was elevated in SD + HFD-fed but not in HFD + SD-fed mice. Blood 
      sinusoid areas, and the number of Ki67-positive cells, a marker of cell 
      proliferation, were elevated in placental labyrinth layer of SD + HFD-fed mice, 
      but decreased in HFD + SD-fed mice. Finally, placental Fatp1, a fatty acid 
      transporter gene, was up-regulated in SD + HFD-fed mice. By contrary, placental 
      Fatp1, and Snat2, an amino acid transporter, were down-regulated in HFD + SD-fed 
      mice. Moreover, the levels of placental FATP4 and SNAT2 were up-regulated in 
      SD + HFD-fed mice. SIGNIFICANCE: HFD before pregnancy and HFD during pregnancy 
      differentially disturb fetal growth development. HFD before pregnancy-induced 
      fetal SGA might be partially attributed to inflammatory cytokines and mediators 
      derived from maternal adipose tissue. By contrary, HFD during pregnancy-induced 
      fetal overweight may be partially attributed to the increase of placental 
      nutrient transport capacity.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Song, Ya-Ping
AU  - Song YP
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; 
      Department of Histology and Embryology, Anhui Medical University, Hefei 230032, 
      China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei 
      230032, China.
FAU - Gao, Lan
AU  - Gao L
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China.
FAU - Wang, Xi-Lu
AU  - Wang XL
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China.
FAU - Luo, Biao
AU  - Luo B
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China.
FAU - Li, Jian
AU  - Li J
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China.
FAU - Xu, De-Xiang
AU  - Xu DX
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China; Anhui 
      Provincial Key Laboratory of Population Health & Aristogenics, Hefei 230032, 
      China. Electronic address: xudex@126.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20181006
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Inflammation Mediators)
RN  - 0 (Pregnancy Proteins)
SB  - IM
MH  - Adipose Tissue/metabolism/pathology
MH  - Animals
MH  - Diet, High-Fat/*adverse effects
MH  - Female
MH  - *Fetal Development
MH  - Inflammation Mediators/*metabolism
MH  - Mice
MH  - Obesity/etiology/physiopathology
MH  - Placenta/*metabolism/pathology
MH  - Pregnancy
MH  - Pregnancy Complications/etiology/*physiopathology
MH  - Pregnancy Proteins/*metabolism
OTO - NOTNLM
OT  - C-reactive protein
OT  - High-fat diets (HFD)
OT  - Overweight
OT  - Placenta
OT  - Small for gestational age (SGA)
EDAT- 2018/10/10 06:00
MHDA- 2018/12/15 06:00
CRDT- 2018/10/10 06:00
PHST- 2018/08/12 00:00 [received]
PHST- 2018/09/29 00:00 [revised]
PHST- 2018/10/06 00:00 [accepted]
PHST- 2018/10/10 06:00 [pubmed]
PHST- 2018/12/15 06:00 [medline]
PHST- 2018/10/10 06:00 [entrez]
AID - S0024-3205(18)30625-8 [pii]
AID - 10.1016/j.lfs.2018.10.008 [doi]
PST - ppublish
SO  - Life Sci. 2018 Nov 1;212:241-250. doi: 10.1016/j.lfs.2018.10.008. Epub 2018 Oct 
      6.