PMID- 30300967
OWN - NLM
STAT- MEDLINE
DCOM- 20200714
LR  - 20200930
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 107
IP  - 4
DP  - 2019 May
TI  - 3D-printed polycaprolactone scaffold mixed with beta-tricalcium phosphate as a bone 
      regenerative material in rabbit calvarial defects.
PG  - 1254-1263
LID - 10.1002/jbm.b.34218 [doi]
AB  - Defect-specific bone regeneration using 3-dimensional (3D) printing of block bone 
      has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be 
      used as 3D scaffold. The aim of this study is to assess the biocompatibility and 
      osteogenic efficacy of 3D printed PCL scaffold and to evaluate the effectiveness 
      of beta-tricalcium phosphate (beta-TCP) addition in PCL scaffold. In this work, four 
      circular defects (diameter: 8 mm) in rabbit calvarium were randomly assigned to 
      (1) negative control (control), (2) PCL block (PCL), (3) PCL mixed with 10 wt% 
      beta-TCP (PCL/beta-TCP), and (4) PCL/beta-TCP plus collagen membrane (PCL/beta-TCP + M). 
      Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Results indicated that 
      in micro-CT, PCL/beta-TCP + M showed the highest total augmented volume and new bone 
      volume at 8 weeks, but there was no significant difference among four groups. 
      Histomorphometrically, PCL, PCL/beta-TCP, and PCL/beta-TCP + M showed the significantly 
      higher total augmented area compared to the control. PCL/beta-TCP + M showed the 
      highest new bone area but not statistically higher than the control. New bone 
      formation deep inside the scaffold was observed only in beta-TCP added scaffold. PCL 
      showed high biocompatibility with great volume maintenance. Addition of beta-TCP to 
      PCL seemed to increase hydrophilicity and osteoconductivity. Developments in 
      3D-printed PCL material are expected. (c) 2018 Wiley Periodicals, Inc. J Biomed 
      Mater Res Part B: Appl Biomater 107B: 1254-1263, 2019.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Pae, Hyung-Chul
AU  - Pae HC
AUID- ORCID: 0000-0002-6365-3557
AD  - Department of Periodontology, Research Institute of Periodontal Regeneration, 
      Yonsei University College of Dentistry, Seoul, South Korea.
FAU - Kang, Joo-Hyun
AU  - Kang JH
AD  - Department of Periodontology, Research Institute of Periodontal Regeneration, 
      Yonsei University College of Dentistry, Seoul, South Korea.
FAU - Cha, Jae-Kook
AU  - Cha JK
AD  - Department of Periodontology, Research Institute of Periodontal Regeneration, 
      Yonsei University College of Dentistry, Seoul, South Korea.
FAU - Lee, Jung-Seok
AU  - Lee JS
AD  - Department of Periodontology, Research Institute of Periodontal Regeneration, 
      Yonsei University College of Dentistry, Seoul, South Korea.
FAU - Paik, Jeong-Won
AU  - Paik JW
AD  - Department of Periodontology, Research Institute of Periodontal Regeneration, 
      Yonsei University College of Dentistry, Seoul, South Korea.
FAU - Jung, Ui-Won
AU  - Jung UW
AD  - Department of Periodontology, Research Institute of Periodontal Regeneration, 
      Yonsei University College of Dentistry, Seoul, South Korea.
FAU - Kim, Byung-Hoon
AU  - Kim BH
AD  - Department of Dental Materials, School of Dentistry, Chosun University, Gwangju, 
      61452, Republic of Korea.
FAU - Choi, Seong-Ho
AU  - Choi SH
AD  - Department of Periodontology, Research Institute of Periodontal Regeneration, 
      Yonsei University College of Dentistry, Seoul, South Korea.
LA  - eng
GR  - NRF-2017R1A2B4002782/National Research Foundation of Korea/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181009
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Calcium Phosphates)
RN  - 0 (Polycarboxylate Cement)
RN  - 0 (beta-tricalcium phosphate)
RN  - 25766-59-0 (polycarbonate)
SB  - IM
MH  - Animals
MH  - *Bone Regeneration
MH  - Calcium Phosphates/*chemistry
MH  - Male
MH  - Polycarboxylate Cement/*chemistry
MH  - *Printing, Three-Dimensional
MH  - Rabbits
MH  - *Skull/injuries/physiology
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - 3D printing
OT  - biocompatible material
OT  - bone regeneration
OT  - polycaprolactone
OT  - beta-tricalcium phosphate
EDAT- 2018/10/10 06:00
MHDA- 2020/07/15 06:00
CRDT- 2018/10/10 06:00
PHST- 2018/05/08 00:00 [received]
PHST- 2018/07/23 00:00 [revised]
PHST- 2018/08/02 00:00 [accepted]
PHST- 2018/10/10 06:00 [pubmed]
PHST- 2020/07/15 06:00 [medline]
PHST- 2018/10/10 06:00 [entrez]
AID - 10.1002/jbm.b.34218 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1254-1263. doi: 
      10.1002/jbm.b.34218. Epub 2018 Oct 9.